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Journal of Clinical Endocrinology & Metabolism, Vol 80, 2419-2429, Copyright © 1995 by Endocrine Society

ARTICLES

Circulating factors and insulin resistance. I. A novel myoinositol 1,2- cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus

GT Galasko, Y Bao, SJ Broomfield, NM Hooper, AJ Turner and J Larner
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA.

A novel low mol wt inositol phosphoglycan inhibitor (M tau 1200-1500) of insulin action in rat adipocytes has been partially purified from normal human plasma. This inhibitor, termed fraction V after the first purification step and fraction V3 after the second, is different from other reported serum insulin antagonists. It contains myoinositol, galactosamine, and mannose in approximate molar ratios of 1:1:3.3. The myoinositol has a 1,2-cyclic phosphate substituent, which is essential for the inhibitory activity. Its inhibitory activity is significantly elevated (161%, P < 0.05 for fraction V; 278%, P < 0.05 for fraction V3) in plasma of humans with noninsulin-dependent diabetes mellitus as compared with plasma of nondiabetic controls. These findings represent the first report of a naturally occurring mammalian inositol 1,2-cyclic phosphate containing phosphoglycan related to insulin action.




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Copyright © 1995 by The Endocrine Society