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Journal of Clinical Endocrinology & Metabolism, Vol 80, 2259-2262, Copyright © 1995 by Endocrine Society
ARTICLES |
AM Nakhla, VD Ding, MS Khan, NA Romas, L Rhodes, RG Smith and W Rosner
Department of Medicine, St. Luke's/Roosevelt Hospital Center, New York, N.Y. 10019, USA.
5 alpha-Androstan-3 alpha, 17 beta-diol (3 alpha-diol) is a well known metabolite of dihydrostestosterone (DHT) and the concentration of its glucuronide in serum is looked upon as a marker of DHT activity in skin and prostate. The data in this communication show that 3 alpha-diol is a potent agonist of the human and canine prostatic SHBG-[SHBG receptor]. It causes a robust rise in intracellular cAMP within minutes; the 1/2 max. response occurs at a concentration equal to its concentration in male plasma. Estradiol is the only other agonist in this system. All other steroids that bind to SHBG are antagonists.
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