Journal of Clinical Endocrinology & Metabolism, Vol 80, 2139-2143, Copyright © 1995 by Endocrine Society

ARTICLES

Insulin-like growth factor-I is related to glycemic control in children and adolescents with newly diagnosed insulin-dependent diabetes

DG Dills, C Allen, M Palta, DJ Zaccaro, R Klein and D D'Alessio
Department of Medicine, University of Wisconsin School of Medicine, Madison 53792, USA.

To address the relationship of insulin-like growth factor-I (IGF-I) to diabetes control, we determined IGF-I levels in 137 subjects age 17 yr and younger with recently diagnosed insulin-dependent diabetes mellitus in a population-based cohort study between 3 and 11 months after diagnosis (mean 4.9 months). Initial determinations of IGF-I, 24-h urine C-peptide and microalbuminuria, age, sex, height, weight, body mass index, pubertal stage, and glycosylated hemoglobin (GHb) were obtained. IGF-I levels ranged from 11-439 ng/mL, were strongly related to age (r = 0.74, P < 0.001), and were higher in females than males at any given age (P < 0.01). IGF-I was inversely related to GHb (partial r = -0.43, P < 0.001) after adjustment for sex and age. The relationship between IGF-I and GHb did not change between age groups (< 6, 6-9, > or = 10 yr of age; P = 0.50), and it did not change between prepubertal and pubertal subjects (P = 0.95). IGF-I was not related to 24-h urine C- peptide or microalbuminuria. These results suggest that lower IGF-I levels are related to poorer metabolic control of diabetes in the period following insulin-dependent diabetes mellitus diagnosis in all young persons regardless of age or pubertal status.

This article has been cited by other articles:

				C. Allen, T. LeCaire, M. Palta, K. Daniels, M. Meredith, and D. J. D'Alessio Risk Factors for Frequent and Severe Hypoglycemia in Type 1 Diabetes Diabetes Care, November 1, 2001; 24(11): 1878 - 1881. [Abstract] [Full Text] [PDF]