Journal of Clinical Endocrinology & Metabolism, Vol 80, 2135-2138, Copyright © 1995 by Endocrine Society

ARTICLES

Attenuation of postmenopausal high turnover bone loss in patients with hypoparathyroidism

K Fujiyama, T Kiriyama, M Ito, K Nakata, S Yamashita, N Yokoyama and S Nagataki
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.

To elucidate the role of PTH in postmenopausal bone loss, we studied 33 postmenopausal patients who received total thyroidectomy due to thyroid carcinoma. Among these patients, 13 were patients with hypoparathyroid function (HPf), and 20 retained normal parathyroid function (NPf) after thyroidectomy. Bone mineral density (BMD), the rate of BMD loss, and incidence of spinal deformity as well as varying bone metabolic markers were analyzed in all patients. The age-matched BMD was clearly higher, and the incidence of spinal deformity was significantly lower in HPf than in NPf. The rate of BMD loss in HPf was significantly lower than in NPf during the early postmenopausal period (within 5 yr after menopause; mean +/- SD, -0.567 +/- 3.05% vs. -2.49 +/- 1.86%/yr, P < 0.05). In contrast, the rates were similar between the two groups during the late postmenopausal period (> 5 yr after menopause). Bone metabolic markers indicated that an accelerated bone turnover occurred during the early postmenopausal period in NPf, but not in HPf. These results suggest that the hypoparathyroid condition provides protection against age-related bone loss. This is due in part to attenuation of the high turnover bone loss that occurs early in menopause.

This article has been cited by other articles:

				D. Miao, J. Li, Y. Xue, H. Su, A. C. Karaplis, and D. Goltzman Parathyroid Hormone-Related Peptide Is Required for Increased Trabecular Bone Volume in Parathyroid Hormone-Null Mice Endocrinology, August 1, 2004; 145(8): 3554 - 3562. [Abstract] [Full Text] [PDF]

				D. Miao, B. He, B. Lanske, X.-Y. Bai, X.-K. Tong, G. N. Hendy, D. Goltzman, and A. C. Karaplis Skeletal Abnormalities in Pth-Null Mice Are Influenced by Dietary Calcium Endocrinology, April 1, 2004; 145(4): 2046 - 2053. [Abstract] [Full Text] [PDF]

				Q. Chen, H. Kaji, M.-F. Iu, R. Nomura, H. Sowa, M. Yamauchi, T. Tsukamoto, T. Sugimoto, and K. Chihara Effects of an Excess and a Deficiency of Endogenous Parathyroid Hormone on Volumetric Bone Mineral Density and Bone Geometry Determined by Peripheral Quantitative Computed Tomography in Female Subjects J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4655 - 4658. [Abstract] [Full Text] [PDF]

				F. K. W. Chan, S.-C. Tiu, K.-L. Choi, C.-H. Choi, A. P. S. Kong, and C.-C. Shek Increased Bone Mineral Density in Patients with Chronic Hypoparathyroidism J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3155 - 3159. [Abstract] [Full Text] [PDF]

				H. M. Perry III The Endocrinology of Aging Clin. Chem., August 1, 1999; 45(8): 1369 - 1376. [Abstract] [Full Text] [PDF]

				Y. Duan, V. De Luca, and E. Seeman Parathyroid Hormone Deficiency and Excess: Similar Effects on Trabecular Bone But Differing Effects on Cortical Bone J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 718 - 722. [Abstract] [Full Text]