help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bjerknes, R.
Right arrow Articles by Aarskog, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bjerknes, R.
Right arrow Articles by Aarskog, D.

Journal of Clinical Endocrinology & Metabolism, Vol 80, 1948-1955, Copyright © 1995 by Endocrine Society

ARTICLES

Priming of human polymorphonuclear neutrophilic leukocytes by insulin- like growth factor I: increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst

R Bjerknes and D Aarskog
Department of Pediatrics, University of Bergen, Haukeland Hospital, Norway.

Insulin-like growth factor I (IGF-I) is a GH-dependent peptide regulating mammalian growth that seems to be of importance for the normal development and function of the immune system. Polymorphonuclear neutrophilic leukocytes (PMNLs) are terminally differentiated phagocytes essential for host defense, and in the present study, recombinant human IGF-I was shown to be a powerful primer of mature human PMNLs. IGF-I augmented the PMNL phagocytosis of both immunoglobulin G-opsonized Staphylococcus aureus and complement- opsonized Candida albicans. In addition, the growth factor increased PMNL complement receptor expression [complement receptors 1 (CD35) and 3 (CD11b)] and primed the cells to stronger f-met-leu-phe-induced degranulation of both specific and azurophilic granules [markers: CD11b, CD35 and CD67 (specific granules); CD63 (azurophilic granules)]. In contrast, IGF-I did not alter the PMNL surface expression of Fc gamma RI (CD64), Fc gamma RII (CDw32), or Fc gamma RIII (CD16). PMNLs exposed to IGF-I increased their f-met-leu-phe and phorbol myristate acetate-induced oxidative burst, as evaluated by hydrogen peroxide production, whereas IGF-I did not influence PMNL actin polymerization. The priming of PMNLs by IGF-I was dependent on time and concentration, and saturating amounts of a monoclonal antibody to the IGF-I receptor blocked the priming of PMNLs by this peptide. These experiments demonstrate that IGF-I can selectively stimulate mature PMNL functions, providing further evidence for the interaction between the immune and the endocrine systems.


This article has been cited by other articles:


Home page
 J EndocrinolHome page
E. Himpe, C. Degaillier, A. Coppens, and R. Kooijman
Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the phosphatidylinositol-3 kinase pathway
J. Endocrinol., October 1, 2008; 199(1): 69 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Walrand, C. Guillet, Y. Boirie, and M.-P. Vasson
Insulin Differentially Regulates Monocyte and Polymorphonuclear Neutrophil Functions in Healthy Young and Elderly Humans
J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2738 - 2748.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M. Sohmiya, I. Kanazawa, and Y. Kato
Effect of recombinant human GH on circulating granulocyte colony-stimulating factor and neutrophils in patients with adult GH deficiency
Eur. J. Endocrinol., February 1, 2005; 152(2): 211 - 215.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Walrand, C. Guillet, Y. Boirie, and M-P. Vasson
In vivo evidences that insulin regulates human polymorphonuclear neutrophil functions
J. Leukoc. Biol., December 1, 2004; 76(6): 1104 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Kooijman, A. Coppens, and E. Hooghe-Peters
IGF-I Inhibits Spontaneous Apoptosis in Human Granulocytes
Endocrinology, April 1, 2002; 143(4): 1206 - 1212.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
S. Ikeda, H. Saito, K. Fukatsu, T. Inoue, I. Han, S. Furukawa, T. Matsuda, and A. Hidemura
Dietary Restriction Impairs Neutrophil Exudation by Reducing CD11b/CD18 Expression and Chemokine Production
Arch Surg, March 1, 2001; 136(3): 297 - 304.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. H. Schacher, R. W. VanHoy, Q. Liu, S. Arkins, R. Dantzer, G. G. Freund, and K. W. Kelley
Developmental Expression of Insulin Receptor Substrate-2 During Dimethylsulfoxide-Induced Differentiation of Human HL-60 Cells
J. Immunol., January 1, 2000; 164(1): 113 - 120.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. B. Solerte, M. Fioravanti, G. Vignati, A. Giustina, L. Cravello, and E. Ferrari
Dehydroepiandrosterone Sulfate Enhances Natural Killer Cell Cytotoxicity in Humans Via Locally Generated Immunoreactive Insulin-Like Growth Factor I
J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3260 - 3267.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1995 by The Endocrine Society