The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women
JL Thompson, GE Butterfield, R Marcus, RL Hintz, M Van Loan, L Ghiron and AR Hoffman
Medical Service, Department of Veterans Affairs Medical Center, Palo Alto, California 94304, USA.
The purpose of this study was to determine the effects of recombinant human
GH (rhGH; 0.025 mg/kg.day) and one of two doses of recombinant human
insulin-like growth factor-I (rhIGF-I; 0.015 and 0.060 mg/kg, twice daily)
on body composition in elderly women. Sixteen healthy elderly women (mean
age +/- SEM, 71.9 +/- 1.3 yr) were randomly assigned to receive either rhGH
(GH; n = 5), low dose rhIGF-I (n = 6), or high dose rhIGF-I (n = 5). A
2-week predrug baseline period was followed by 4 weeks of hormone
treatment, with a standardized diet fed throughout. All groups experienced
a significant increase in serum IGF- I and IGFBP-3 levels over the
treatment period, accompanied by significant decreases in IGF-II (P <
0.05). Fat mass decreased in all groups, with significant increases in lean
body mass and nitrogen retention occurring in the high dose IGF and GH
groups. Total body water did not change, whereas increases observed in
intracellular fluid approached significance (P = 0.06). These anabolic
changes were accompanied by numerous negative side-effects in the GH and
high dose IGF groups, including headaches, lethargy, joint swelling/pain,
and bloatedness. The low IGF dose was well tolerated. These results
demonstrate that the administration of rhGH and rhIGF-I for 4 weeks results
in anabolic changes in body composition in elderly women.
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