Journal of Clinical Endocrinology & Metabolism, Vol 80, 504-507, Copyright © 1995 by Endocrine Society

ARTICLES

The serotonin-4 receptor agonist cisapride and angiotensin-II exert additive effects on aldosterone secretion in normal man

H Lefebvre, V Contesse, C Delarue, A Legrand, JM Kuhn, H Vaudry and LM Wolf
European Institute for Peptide Research, Group for Hormone Research, Rouen, France.

In animals and man, serotonin (5-HT) exerts a direct stimulatory action on adrenocortical cells through activation of 5-HT4 receptors. In rats, 5-HT also potentiates the stimulatory effect of angiotensin-II (Ang II) on aldosterone secretion. The aim of the present study was to investigate the effect of concomitant administration of the 5-HT4 receptor agonist, cisapride, and Ang II on aldosterone secretion in normal human subjects. Eight healthy male volunteers pretreated with dexamethasone received, at 1-week intervals in random order and simple blind fashion, the following treatments: 1) a single oral dose of 10 mg cisapride, 2) a single oral dose of placebo, 3) a perfusion of graded doses of Ang II (from 1-4 ng/kg.min), 4) a perfusion of placebo, and 5) a single oral dose of 10 mg cisapride associated with a perfusion of Ang II. The oral doses of cisapride and placebo were also administered after a 3-day period of a low sodium diet (10 mmol/day). Plasma aldosterone levels increased significantly within 90 min after the administration of cisapride without any change in renin levels. The comparison between the net increase in aldosterone production induced by cisapride, Ang II, and cisapride plus Ang II showed that the stimulatory effects of cisapride and Ang II on aldosterone secretion were only additive. Similarly, the increase in plasma aldosterone levels induced by a sodium-restricted diet was just additive with the cisapride-evoked stimulation of aldosterone secretion. These results provide further evidence that the action of 5-HT on glomerulosa cells is mediated through activation of 5-HT4 receptors. The data also indicate that in humans, 5-HT does not potentiate the stimulatory effect of Ang II on aldosterone secretion.

This article has been cited by other articles:

				D. Cartier, S. Jegou, F. Parmentier, I. Lihrmann, E. Louiset, J.-M. Kuhn, C. Bastard, P.-F. Plouin, M. Godin, H. Vaudry, et al. Expression profile of serotonin4 (5-HT4) receptors in adrenocortical aldosterone-producing adenomas Eur. J. Endocrinol., December 1, 2005; 153(6): 939 - 947. [Abstract] [Full Text] [PDF]

				V. Contesse, Y. Reznik, E. Louiset, C. Duparc, D. Cartier, F. Sicard, A. Laquerriere, F. Parmentier, J.-M. Kuhn, H. Vaudry, et al. Abnormal Sensitivity of Cortisol-Producing Adrenocortical Adenomas to Serotonin: In Vivo and in Vitro Studies J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2843 - 2850. [Abstract] [Full Text] [PDF]

				J. Bertherat, V. Contesse, E. Louiset, G. Barrande, C. Duparc, L. Groussin, P. Emy, X. Bertagna, J.-M. Kuhn, H. Vaudry, et al. In Vivo and in Vitro Screening for Illegitimate Receptors in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Causing Cushing's Syndrome: Identification of Two Cases of Gonadotropin/Gastric Inhibitory Polypeptide-Dependent Hypercortisolism J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1302 - 1310. [Abstract] [Full Text] [PDF]

				M. Mannelli, P. Ferruzzi, P. Luciani, C. Crescioli, L. Buci, G. Corona, M. Serio, and A. Peri Cushing's Syndrome in a Patient with Bilateral Macronodular Adrenal Hyperplasia Responding to Cisapride: An in Vivo and in Vitro Study J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4616 - 4622. [Abstract] [Full Text] [PDF]

				D. Cartier, I. Lihrmann, F. Parmentier, C. Bastard, J. Bertherat, P. Caron, J.-M. Kuhn, A. Lacroix, A. Tabarin, J. Young, et al. Overexpression of Serotonin4 Receptors in Cisapride-Responsive Adrenocorticotropin-Independent Bilateral Macronodular Adrenal Hyperplasia Causing Cushing's Syndrome J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 248 - 254. [Abstract] [Full Text] [PDF]

				H. Lefebvre, P. Compagnon, V. Contesse, C. Delarue, C. Thuillez, H. Vaudry, and J.-M. Kuhn Production and Metabolism of Serotonin (5-HT) by the Human Adrenal Cortex: Paracrine Stimulation of Aldosterone Secretion by 5-HT J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 5001 - 5007. [Abstract] [Full Text] [PDF]

				A. Lacroix, N. N'Diaye, J. Tremblay, and P. Hamet Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome Endocr. Rev., February 1, 2001; 22(1): 75 - 110. [Abstract] [Full Text]

				M. Ehrhart-Bornstein, J. P. Hinson, S. R. Bornstein, W. A. Scherbaum, and G. P. Vinson Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis Endocr. Rev., April 1, 1998; 19(2): 101 - 143. [Abstract] [Full Text]