| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 80, 412-417, Copyright © 1995 by Endocrine Society
ARTICLES |
PJ Trainer, M Faria, J Newell-Price, P Browne, P Kopelman, DH Coy, GM Besser and AB Grossman
Department of Endocrinology, St. Bartholomew's Hospital, West Smithfield, London, United Kingdom.
To compare the clinical efficacy of ovine and human sequence corticotropin-releasing hormone (CRH), we examined the effects of both peptides on ACTH and cortisol secretion in normal human volunteers, obese subjects, and patients with pituitary-dependent (Cushing's disease) and adrenal-dependent Cushing's syndrome. All subjects in each group were studied twice in random order. One hundred micrograms of CRH were administered as an iv bolus through an in-dwelling forearm cannula at 0930 h, and thereafter, blood was drawn every 15 min for 2 h for the measurement of ACTH and cortisol. In the normal subjects, the peak ACTH, peak incremental ACTH, and mean area under the curve after CRH treatment were greater with ovine CRH than human CRH, although there was no difference in the cortisol response, however it was analyzed. There was no difference in the ACTH or cortisol response to the two preparations in the obese subjects, and no significant difference was found, for either cortisol or ACTH, between obese subjects and normal volunteers. With both varieties of CRH, Cushing's disease resulted in greater responses for ACTH and cortisol than those seen in the other 2 groups (P < 0.001 for all comparisons), but there was no difference between the sequences. However, a significant cortisol response, defined as an increase of greater than 4 times the coefficient of variation of the assay (24%), was seen in all 10 Cushing's patients with human CRH, but in only 8 with ovine CRH. In 3 patients with adrenal tumors, serum cortisol did not change after the administration of either preparation, whereas plasma ACTH remained undetectable throughout the study. We suggest that although ovine sequence CRH causes more prolonged and greater ACTH, and possibly cortisol, secretion compared to human CRH, the discriminatory value of the CRH test, in terms of either the diagnosis or differential diagnosis of Cushing's syndrome, is comparable for the two peptide sequences.
This article has been cited by other articles:
 |
|
 |
|
  N. M. Martin, W. S. Dhillo, A. Banerjee, A. Abdulali, C. N. Jayasena, M. Donaldson, J. F. Todd, and K. Meeran Comparison of the Dexamethasone-Suppressed Corticotropin-Releasing Hormone Test and Low-Dose Dexamethasone Suppression Test in the Diagnosis of Cushing's Syndrome J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2582 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. V. Ward, H. E. Syddall, P. J. Wood, G. P. Chrousos, and D. I. W. Phillips Fetal Programming of the Hypothalamic-Pituitary-Adrenal (HPA) Axis: Low Birth Weight and Central HPA Regulation J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1227 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Schmidt, H. Lahner, K. Mann, and S. Petersenn Diagnosis of Adrenal Insufficiency: Evaluation of the Corticotropin-Releasing Hormone Test and Basal Serum Cortisol in Comparison to the Insulin Tolerance Test in Patients with Hypothalamic-Pituitary-Adrenal Disease J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4193 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Newell-Price, D. G. Morris, W. M. Drake, M. Korbonits, J. P. Monson, G. M. Besser, and A. B. Grossman Optimal Response Criteria for the Human CRH Test in the Differential Diagnosis of ACTH-Dependent Cushing's Syndrome J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1640 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsagarakis, C. Tsigos, V. Vasiliou, P. Tsiotra, J. Kaskarelis, C. Sotiropoulou, S. A. Raptis, and N. Thalassinos The Desmopressin and Combined CRH-Desmopressin Tests in the Differential Diagnosis of ACTH-Dependent Cushing's Syndrome: Constraints Imposed by the Expression of V2 Vasopressin Receptors in Tumors with Ectopic ACTH Secretion J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1646 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Jessop, M. F. Dallman, D. Fleming, and S. L. Lightman Resistance to Glucocorticoid Feedback in Obesity J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4109 - 4114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Karlsson, J. Kallio, K. Irjala, S. Ekblad, J. Toppari, and P. Kero Adrenocorticotropin and Corticotropin-Releasing Hormone Tests in Preterm Infants J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4592 - 4595. [Abstract] [Full Text]
|
|
|
|
 |
|
 T.M. O'CONNOR, D.J. O'HALLORAN, and F. SHANAHAN The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia QJM, June 1, 2000; 93(6): 323 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Korbonits, G. Kaltsas, L. A. Perry, P. Putignano, A. B. Grossman, G. M. Besser, and P. J. Trainer The Growth Hormone Secretagogue Hexarelin Stimulates the Hypothalamo-Pituitary-Adrenal Axis via Arginine Vasopressin J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2489 - 2495. [Abstract] [Full Text]
|
|
|
|
|
|
G. A. Kaltsas, M. G. Giannulis, J. D. C. Newell-Price, J. E. Dacie, C. Thakkar, F. Afshar, J. P. Monson, A. B. Grossman, G. M. Besser, and P. J. Trainer A Critical Analysis of the Value of Simultaneous Inferior Petrosal Sinus Sampling in Cushing's Disease and the Occult Ectopic Adrenocorticotropin Syndrome J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 487 - 492. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Newell-Price, P. Trainer, M. Besser, and A. Grossman The Diagnosis and Differential Diagnosis of Cushing's Syndrome and Pseudo-Cushing's States Endocr. Rev., October 1, 1998; 19(5): 647 - 672. [Abstract] [Full Text]
|
|
|
|
|
|
J. Mayenknecht, S. Diederich, V. Bähr, U. Plöckinger, and W. Oelkers Comparison of Low and High Dose Corticotropin Stimulation Tests in Patients with Pituitary Disease J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1558 - 1562. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. Trainer, R. J. Woods, M. Korbonits, V. Popovic, P. M. Stewart, P. J. Lowry, and A. B. Grossman The Pathophysiology of Circulating Corticotropin-Releasing Hormone-Binding Protein Levels in the Human J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1611 - 1614. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. E. Davis, L. T. A. Thu, T. Q. Binh, K. Robertson, J. R. Dyer, P. T. Danh, D. Meyer, M. H. Beaman, and T. K. Anh The Hypothalamic-Pituitary-Adrenocortical Axis in Severe Falciparum Malaria: Effects of Cytokines J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3029 - 3033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Yanovski, S. Z. Yanovski, P. W. Gold, and G. P. Chrousos Differences in Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol before and after Weight Loss J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1874 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Ng, G. W. K. Wong, C. W. K. Lam, C. H. Lee, M. Y. Wong, T. F. Fok, W. Wong, and D. C. F. Chan The Pituitary-Adrenal Responses to Exogenous Human Corticotropin-Releasing Hormone in Preterm, Very Low Birth Weight Infants J. Clin. Endocrinol. Metab., March 1, 1997; 82(3): 797 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Newell-Price, L. Perry, S. Medbak, J. Monson, M. Savage, M. Besser, and A. Grossman A Combined Test Using Desmopressin and Corticotropin-Releasing Hormone in the Differential Diagnosis of Cushing's Syndrome J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 176 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Oelkers Adrenal Insufficiency N. Engl. J. Med., October 17, 1996; 335(16): 1206 - 1212. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
