Journal of Clinical Endocrinology & Metabolism, Vol 80, 406-411, Copyright © 1995 by Endocrine Society

ARTICLES

An investigation of sources of variation in calcium absorption efficiency [published erratum appears in J Clin Endocrinol Metab 1995 Jul;80(7):2068]

MJ Barger-Lux, RP Heaney, SJ Lanspa, JC Healy and HF DeLuca
Department of Internal Medicine, Creighton University School of Medicine, Omaha, Nebraska 68131.

To examine putative sources of interindividual variation in calcium absorption efficiency, we studied 41 healthy premenopausal women (mean age, 36.4 yr). About half were randomized to pretreatment with supplemental 25-hydroxyvitamin D (25OHD; 20 micrograms/day [corrected] for approximately 34 days) before testing. We measured dietary factors, humoral regulators, intestinal motility, mucosal histology, mucosal vitamin D receptor levels, and calcium absorption efficiency. In winter tests, but not in summer tests, calcium absorption fraction was significantly higher in the pretreated group (mean, 0.465 vs. 0.387). Serum 25OHD, intestinal transit, and urinary calcium to creatinine ratio were all significantly and positively correlated to calcium absorption efficiency. However, neither the level of 1,25- dihydroxyvitamin D receptors in duodenal mucosa nor circulating 1,25- dihydroxyvitamin D was related to calcium absorption efficiency. These findings, which are consistent with other published human data, suggest that 25OHD plays a more prominent role in the regulation of calcium absorption than is generally believed. In a multiple regression model, serum 25OHD, mouth to cecum transit time, and fasting urinary calcium/creatinine ratio explained 44% of the observed variation in calcium absorption efficiency.

This article has been cited by other articles:

				H. Tanimoto, T. Fox, J. Eagles, H. Satoh, H. Nozawa, A. Okiyama, Y. Morinaga, and S. J. Fairweather-Tait Acute Effect of Poly-{gamma}-Glutamic Acid on Calcium Absorption in Post-Menopausal Women J. Am. Coll. Nutr., December 1, 2007; 26(6): 645 - 649. [Abstract] [Full Text] [PDF]

				J. M Lappe, D. Travers-Gustafson, K M. Davies, R. R Recker, and R. P Heaney Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial Am. J. Clinical Nutrition, June 1, 2007; 85(6): 1586 - 1591. [Abstract] [Full Text] [PDF]

				B. Teucher, G. Majsak-Newman, J. R Dainty, D. McDonagh, R. J FitzGerald, and S. J Fairweather-Tait Calcium absorption is not increased by caseinophosphopeptides Am. J. Clinical Nutrition, July 1, 2006; 84(1): 162 - 166. [Abstract] [Full Text] [PDF]

				J. L. Rosado, M. Diaz, A. Rosas, I. Griffit, and O. P. Garcia Calcium Absorption from Corn Tortilla Is Relatively High and Is Dependent upon Calcium Content and Liming in Mexican Women J. Nutr., November 1, 2005; 135(11): 2578 - 2581. [Abstract] [Full Text] [PDF]

				M. J. Barger-Lux and R. P. Heaney Calcium Absorptive Efficiency Is Positively Related to Body Size J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5118 - 5120. [Abstract] [Full Text] [PDF]

				J. C Fleet Genomic and proteomic approaches for probing the role of vitamin D in health Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1730S - 1734S. [Abstract] [Full Text] [PDF]

				C. M. Weaver 2003 W. O. Atwater Memorial Lecture: Defining Nutrient Requirements from a Perspective of Bone-Related Nutrients J. Nutr., December 1, 2003; 133(12): 4063 - 4066. [Full Text] [PDF]

				K. J Schulze, K. O O'Brien, E. L Germain-Lee, D. J Baer, A. Leonard, and B. J Rosenstein Efficiency of calcium absorption is not compromised in clinically stable prepubertal and pubertal girls with cystic fibrosis Am. J. Clinical Nutrition, July 1, 2003; 78(1): 110 - 116. [Abstract] [Full Text] [PDF]

				A. Devine, S. G Wilson, I. M Dick, and R. L Prince Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women Am. J. Clinical Nutrition, February 1, 2002; 75(2): 283 - 288. [Abstract] [Full Text]

				N.K. Arden, P. Major, J.R. Poole, R.W. Keen, S. Vaja, R. Swaminathan, C. Cooper, and T.D. Spector Size at birth, adult intestinal calcium absorption and 1,25(OH)2 vitamin D QJM, January 1, 2002; 95(1): 15 - 21. [Abstract] [Full Text] [PDF]

				L. Sax The Institute of Medicine's "Dietary Reference Intake" for Phosphorus: A Critical Perspective J. Am. Coll. Nutr., August 1, 2001; 20(4): 271 - 278. [Abstract] [Full Text] [PDF]

				R. P. Heaney Factors Influencing the Measurement of Bioavailability, Taking Calcium as a Model J. Nutr., April 1, 2001; 131(4): 1344S - 1348. [Abstract] [Full Text]

				N. F. Barley, A. Howard, D. O'Callaghan, S. Legon, and J. R. F. Walters Epithelial calcium transporter expression in human duodenum Am J Physiol Gastrointest Liver Physiol, February 1, 2001; 280(2): G285 - G290. [Abstract] [Full Text] [PDF]

				R. J Wood Searching for the determinants of intestinal calcium absorption Am. J. Clinical Nutrition, September 1, 2000; 72(3): 675 - 676. [Full Text] [PDF]

				R. P Heaney Dietary protein and phosphorus do not affect calcium absorption Am. J. Clinical Nutrition, September 1, 2000; 72(3): 758 - 761. [Abstract] [Full Text] [PDF]

				R. L Wolf, J. A Cauley, C. E Baker, R. E Ferrell, M. Charron, A. W Caggiula, L. M Salamone, R. P Heaney, and L. H Kuller Factors associated with calcium absorption efficiency in pre- and perimenopausal women Am. J. Clinical Nutrition, August 1, 2000; 72(2): 466 - 471. [Abstract] [Full Text] [PDF]

				R. Vieth Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety Am. J. Clinical Nutrition, May 1, 1999; 69(5): 842 - 856. [Abstract] [Full Text] [PDF]

				G. Vezzoli, I. Baragetti, S. Zerbi, A. Caumo, L. Soldati, P. Bellinzoni, A. Centemero, A. Rubinacci, G. Moro, and G. Bianchi Strontium absorption and excretion in normocalciuric subjects: relation tocalcium metabolism Clin. Chem., March 1, 1998; 44(3): 586 - 590. [Abstract] [Full Text] [PDF]

				H. W. Woitge, C. Scheidt-Nave, C. Kissling, G. Leidig-Bruckner, K. Meyer, A. Grauer, S. H. Scharla, R. Ziegler, and M. J. Seibel Seasonal Variation of Biochemical Indexes of Bone Turnover: Results of a Population-Based Study J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 68 - 75. [Abstract] [Full Text]

				R. P. Heaney, M. J. Barger-Lux, M. S. Dowell, T. C. Chen, and M. F. Holick Calcium Absorptive Effects of Vitamin D and Its Major Metabolites J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4111 - 4116. [Abstract] [Full Text] [PDF]