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Journal of Clinical Endocrinology & Metabolism, Vol 80, 4-4, Copyright © 1995 by Endocrine Society

ARTICLES

P53 protein accumulates in Cushings adenomas and invasive non- functional adenomas [corrected and republished article originally printed in J Clin Endocrinol Metab 1994 Nov;79(5):1513-6]

N Buckley, AS Bates, JC Broome, RC Strange, CW Perrett, CW Burke and RN Clayton
School of Postgraduate Medicine, Keele University, North Staffordshire Hospital Centre, Stoke on Trent, UK.

The p53 protein, a negative regulator of cell growth, plays an important role in the pathogenesis of many human tumours following gene mutation and/or deletion. We screened a large number of sporadic pituitary tumours for p53 protein accumulation suggestive of gene mutation. Samples were divided into benign adenomas (n = 95) and invasive tumours with local or distant invasion (n = 26). All main tumour classes were represented. Putative p53 mutations were detected by immunohistochemistry on paraffin-embedded sections using polyclonal CM-1 and monoclonal DO-7 and PAb1801 antibodies. Results were compared to normal post-mortem pituitary tissue controls (n = 17). p53 protein accumulation was detected in invasive tumours (16%), but only in corticotrophinomas (2/4) and non-functional tumours (4/15). In non- invasive adenomas, protein accumulation was observed only in ACTH- secreting tumours where 50% were positive (16/32). No protein accumulation was identified in any control tissue. These results indicate that p53 protein accumulation may play a role in the development of Cushings adenomas and in the progression of non- functional tumours to the invasive state.


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