| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 80, 3209-3222, Copyright © 1995 by Endocrine Society
ARTICLES |
JD Veldhuis, AY Liem, S South, A Weltman, J Weltman, DA Clemmons, R Abbott, T Mulligan, ML Johnson and S Pincus
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
A chemiluminescence-based GH assay with 30- to 100-fold increased sensitivity recently disclosed combined basal and pulsatile GH secretion in men. However, how age, sex steroid hormones, and obesity singly and jointly influence the basal vs. pulsatile modes of GH release is not known. We used the foregoing assay (detection threshold, 0.002-0.005 microgram/L) and high sensitivity and specificity (> or = 90% each) deconvolution analysis to quantitate basal and pulsatile GH secretion from 24-h serum GH concentration profiles in 26 healthy lean and obese men, whose ages spanned 18-63 yr and whose percentage body fat ranged from 12-47%. Concentrations of serum insulin-like growth factor I (IGF-I), IGF-I-binding protein-1 (IGFBP-1), and IGFBP-3 were related to specific measures of basal or pulsatile GH release. We observed that mean (24-h) serum GH concentrations embraced a 140-fold range from 0.013-1.8 micrograms/L and were related negatively to age (r = -0.50; P < 0.01), percentage body fat (r = -0.620; P < 0.01), and their interaction (r = -0.610; P < 0.01). In contrast, testosterone was a robustly positive statistical determinant of mean serum GH values (r = 0.628; P = 0.0006). Stepwise multivariate regression analysis disclosed that percentage body fat alone and jointly with the serum testosterone concentration controlled, respectively, 38% and 50% of the total variability in GH levels (P = 0.0013 and P = 0.0008). As assessed by deconvolution analysis, GH secretory burst mass was negatively related to percentage body fat (r = -0.621; P < 0.01) and positively to serum testosterone (r = 0.529; P = 0.0054). The calculated half-life of GH correlated positively with serum estradiol (r = 0.447; P = 0.032), and negatively with percentage body fat (r = -0.437; P = 0.048). Basal GH secretion rates were negatively related to serum estradiol (r = - 0.485; P = 0.016). In contrast, GH secretory burst frequency and duration were unrelated to age, percentage body fat, or sex steroids. The fraction of total GH secreted in bursts was negatively correlated with the body mass index (r = -0.540; P < 0.01). Serum IGF-I concentrations were positively related to total pulsatile GH secretion (r = 0.690; P = 0.0011) and negatively to age (r = -0.597; P = 0.007) and percentage body fat (r = -0.611; P = 0.009).(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
 |
|
 |
|
  J. E. Puche, M. Garcia-Fernandez, J. Muntane, J. Rioja, S. Gonzalez-Baron, and I. Castilla Cortazar Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats Endocrinology, May 1, 2008; 149(5): 2620 - 2627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Paulo, M. Cosma, C. Soares-Welch, J. N. Bailey, K. L. Mielke, J. M. Miles, C. Y. Bowers, and J. D. Veldhuis Gonadal Status and Body Mass Index Jointly Determine Growth Hormone (GH)-Releasing Hormone/GH-Releasing Peptide Synergy in Healthy Men J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 944 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gibney, M.-L. Healy, and P. H. Sonksen The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport Endocr. Rev., October 1, 2007; 28(6): 603 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Muniyappa, J. D. Sorkin, J. D. Veldhuis, S. M. Harman, T. Munzer, S. Bhasin, and M. R. Blackman Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E769 - E775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wideman, L. Consitt, J. Patrie, B. Swearingin, R. Bloomer, P. Davis, and A. Weltman The impact of sex and exercise duration on growth hormone secretion J Appl Physiol, December 1, 2006; 101(6): 1641 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ionescu and L. A. Frohman Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4792 - 4797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Franco, J. D Veldhuis, A. Iranmanesh, J. Brandberg, L. Lonn, B. Andersson, B.-A. Bengtsson, J. Svensson, and G. Johannsson Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity. Eur. J. Endocrinol., August 1, 2006; 155(2): 261 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Svensson, G. Johannsson, A. Iranmanesh, K. Albertsson-Wikland, J. D Veldhuis, and B.-A. Bengtsson GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood. Eur. J. Endocrinol., July 1, 2006; 155(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Weltman, J. Y. Weltman, C. P. Roy, L. Wideman, J. Patrie, W. S. Evans, and J. D. Veldhuis Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults J Appl Physiol, May 1, 2006; 100(5): 1623 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Munzer, C. J. Rosen, S.M. Harman, K. M. Pabst, C. St. Clair, J. D. Sorkin, and M. R. Blackman Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E1006 - E1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D Veldhuis, J. M Patrie, K. Frick, J. Y Weltman, and A. L Weltman Administration of recombinant human GHRH-1,44-amide for 3 months reduces abdominal visceral fat mass and increases physical performance measures in postmenopausal women Eur. J. Endocrinol., November 1, 2005; 153(5): 669 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, A. Iranmanesh, and C. Y. Bowers Joint Mechanisms of Impaired Growth-Hormone Pulse Renewal in Aging Men J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4177 - 4183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Morimoto, P. A. Newcomb, E. White, J. Bigler, and J. D. Potter Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1394 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Darzy, S. S. Pezzoli, M. O. Thorner, and S. M. Shalet The Dynamics of Growth Hormone (GH) Secretion in Adult Cancer Survivors with Severe GH Deficiency Acquired after Brain Irradiation in Childhood for Nonpituitary Brain Tumors: Evidence for Preserved Pulsatility and Diurnal Variation with Increased Secretory Disorderliness J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2794 - 2803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, L. Farhy, A. L. Weltman, J. Kuipers, J. Weltman, and L. Wideman Gender Modulates Sequential Suppression and Recovery of Pulsatile Growth Hormone Secretion by Physiological Feedback Signals in Young Adults J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2874 - 2881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Smith, L. Betancourt, and Y. Sun Molecular Endocrinology and Physiology of the Aging Central Nervous System Endocr. Rev., April 1, 2005; 26(2): 203 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, S. M. Anderson, A. Iranmanesh, and C. Y. Bowers Testosterone Blunts Feedback Inhibition of Growth Hormone Secretion by Experimentally Elevated Insulin-Like Growth Factor-I Concentrations J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1613 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L Boguszewski, L. H F Meister, D. C T Zaninelli, and R. B Radominski One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults Eur. J. Endocrinol., January 1, 2005; 152(1): 67 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Koutkia, B. Canavan, J. Breu, and S. Grinspoon Growth Hormone (GH) Responses to GH-Releasing Hormone-Arginine Testing in Human Immunodeficiency Virus Lipodystrophy J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. T. Patrie, K. T. Brill, J. Y. Weltman, E. E. Mueller, C. Y. Bowers, and A. Weltman Contributions of Gender and Systemic Estradiol and Testosterone Concentrations to Maximal Secretagogue Drive of Burst-Like Growth Hormone Secretion in Healthy Middle-Aged and Older Adults J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6291 - 6296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. T. Patrie, K. Frick, J. Y. Weltman, and A. Weltman Sustained Growth Hormone (GH) and Insulin-Like Growth Factor I Responses to Prolonged High-Dose Twice-Daily GH-Releasing Hormone Stimulation in Middle-Aged and Older Men J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6325 - 6330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. Y. Weltman, A. L. Weltman, A. Iranmanesh, E. E. Muller, and C. Y. Bowers Age and Secretagogue Type Jointly Determine Dynamic Growth Hormone Responses to Exogenous Insulin-Like Growth Factor-Negative Feedback in Healthy Men J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5542 - 5548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Girod and D. J. Brotman Does altered glucocorticoid homeostasis increase cardiovascular risk? Cardiovasc Res, November 1, 2004; 64(2): 217 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iranmanesh, C. Y. Bowers, and J. D. Veldhuis Activation of Somatostatin-Receptor Subtype-2/-5 Suppresses the Mass, Frequency, and Irregularity of Growth Hormone (GH)-Releasing Peptide-2-Stimulated GH Secretion in Men J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4581 - 4587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y. Bowers, R. Granda, S. Mohan, J. Kuipers, D. Baylink, and J. D. Veldhuis Sustained Elevation of Pulsatile Growth Hormone (GH) Secretion and Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-3 (IGFBP-3), and IGFBP-5 Concentrations during 30-Day Continuous Subcutaneous Infusion of GH-Releasing Peptide-2 in Older Men and Women J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2290 - 2300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kok, M. M. Buijs, S. W. Kok, I. H. A. P. van Ierssel, M. Frolich, F. Roelfsema, P. J. Voshol, A. E. Meinders, and H. Pijl Acipimox enhances spontaneous growth hormone secretion in obese women Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R693 - R698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, W. S. Evans, A. Iranmanesh, A. L. Weltman, and C. Y. Bowers Short-Term Testosterone Supplementation Relieves Growth Hormone Autonegative Feedback in Men J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1285 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, S. M. Anderson, P. Kok, A. Iranmanesh, J. Frystyk, H. Orskov, and D. M. Keenan Estradiol Supplementation Modulates Growth Hormone (GH) Secretory-Burst Waveform and Recombinant Human Insulin-Like Growth Factor-I-Enforced Suppression of Endogenously Driven GH Release in Postmenopausal Women J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1312 - 1318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. Patrie, L. Wideman, M. Patterson, J. Y. Weltman, and A. Weltman Contrasting Negative-Feedback Control of Endogenously Driven and Exercise-Stimulated Pulsatile Growth Hormone Secretion in Women and Men J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 840 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Koutkia, G. Meininger, B. Canavan, J. Breu, and S. Grinspoon Metabolic regulation of growth hormone by free fatty acids, somatostatin, and ghrelin in HIV-lipodystrophy Am J Physiol Endocrinol Metab, February 1, 2004; 286(2): E296 - E303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Misra, K. K. Miller, J. Bjornson, A. Hackman, A. Aggarwal, J. Chung, M. Ott, D. B. Herzog, M. L. Johnson, and A. Klibanski Alterations in Growth Hormone Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5615 - 5623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Schmitt, J. Obry, R. Feneberg, J. D. Veldhuis, O. Mehls, E. Ritz, and F. Schaefer {beta}1-Adrenergic Blockade Augments Pulsatile PTH Secretion in Humans J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3245 - 3250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Klerman, G. K. Adler, M. Jin, A. M. Maliszewski, and E. N. Brown A statistical model of diurnal variation in human growth hormone Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1118 - E1126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Rennie Claims for the anabolic effects of growth hormone: a case of the Emperor's new clothes? Br. J. Sports Med., April 1, 2003; 37(2): 100 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Brill, A. L. Weltman, A. Gentili, J. T. Patrie, D. A. Fryburg, J. B. Hanks, R. J. Urban, and J. D. Veldhuis Single and Combined Effects of Growth Hormone and Testosterone Administration on Measures of Body Composition, Physical Performance, Mood, Sexual Function, Bone Turnover, and Muscle Gene Expression in Healthy Older Men J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5649 - 5657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-C. Leung, C. Howe, L. Y.-Y. Gui, G. Trout, J. D. Veldhuis, and K. K. Y. Ho Physiological and pharmacological regulation of 20-kDa growth hormone Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E836 - E843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. C. M. van Dam, F. Roelfsema, F. H. Helmerhorst, M. Frolich, A. E. Meinders, J. D. Veldhuis, and H. Pijl Low Amplitude and Disorderly Spontaneous Growth Hormone Release in Obese Women with or without Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4225 - 4230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. O'Connell and D. R. Clemmons IGF-I/IGF-Binding Protein-3 Combination Improves Insulin Resistance By GH-Dependent and Independent Mechanisms J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4356 - 4360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Richmond, A. D. Rogol, D. Basdemir, O. L. Veldhuis, W. Clarke, C. Y. Bowers, and J. D. Veldhuis Accelerated Escape from GH Autonegative Feedback in Midpuberty in Males: Evidence for Time-Delimited GH-Induced Somatostatinergic Outflow in Adolescent Boys J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3837 - 3844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lucidi, N. Parlanti, F. Piccioni, F. Santeusanio, and P. de Feo Short-Term Treatment with Low Doses of Recombinant Human GH Stimulates Lipolysis in Visceral Obese Men J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3105 - 3109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Svensson, J. D. Veldhuis, A. Iranmanesh, B.-A. Bengtsson, and G. Johannsson Increased Orderliness of Growth Hormone (GH) Secretion in GH-Deficient Adults with Low Serum Insulin-Like Growth Factor I J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2863 - 2869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Hansen, J. O. L. Jorgensen, and J. S. Christiansen Body Composition and Circulating Levels of Insulin, Insulin-Like Growth Factor-Binding Protein-1 and Growth Hormone (GH)-Binding Protein Affect the Pharmacokinetics of GH in Adults Independently of Age J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2185 - 2193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gentili, T. Mulligan, M. Godschalk, J. Clore, J. Patrie, A. Iranmanesh, and J. D. Veldhuis Unequal Impact of Short-Term Testosterone Repletion on the Somatotropic Axis of Young and Older Men J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 825 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lado-Abeal, J. D. Veldhuis, and R. L. Norman Glucose Relays Information Regarding Nutritional Status to the Neural Circuits That Control the Somatotropic, Corticotropic, and Gonadotropic Axes in Adult Male Rhesus Macaques Endocrinology, February 1, 2002; 143(2): 403 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. PINCUS Assessing Serial Irregularity and Its Implications for Health Ann. N.Y. Acad. Sci., December 1, 2001; 954(1): 245 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-G. Roh, G.-Y. Nie, K. Loneragan, A. Gertler, and C. Chen Direct Modification of Somatotrope Function by Long-Term Leptin Treatment of Primary Cultured Ovine Pituitary Cells Endocrinology, December 1, 2001; 142(12): 5167 - 5171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, M. L. Johnson, O. L. Veldhuis, M. Straume, and S. M. Pincus Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1975 - R1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, A. Iranmanesh, D. Naftolowitz, N. Tatham, F. Cassidy, and B. J. Carroll Corticotropin Secretory Dynamics in Humans under Low Glucocorticoid Feedback J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5554 - 5563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Lo, K. Mulligan, M. A. Noor, J.-M. Schwarz, R. A. Halvorsen, C. Grunfeld, and M. Schambelan The Effects of Recombinant Human Growth Hormone on Body Composition and Glucose Metabolism in HIV-Infected Patients with Fat Accumulation J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3480 - 3487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, S. M. Pincus, M. C. Garcia-Rudaz, M. G. Ropelato, M. E. Escobar, and M. Barontini Disruption of the Synchronous Secretion of Leptin, LH, and Ovarian Androgens in Nonobese Adolescents with the Polycystic Ovarian Syndrome J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3772 - 3778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Clasey, A. Weltman, J. Patrie, J. Y. Weltman, S. Pezzoli, C. Bouchard, M. O. Thorner, and M. L. Hartman Abdominal Visceral Fat and Fasting Insulin Are Important Predictors of 24-Hour GH Release Independent of Age, Gender, and Other Physiological Factors J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3845 - 3852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Bray, T. M. Vick, N. Shah, S. M. Anderson, L. W. Rice, A. Iranmanesh, W. S. Evans, and J. D. Veldhuis Short-Term Estradiol Replacement in Postmenopausal Women Selectively Mutes Somatostatin's Dose-Dependent Inhibition of Fasting Growth Hormone Secretion J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3143 - 3149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gusenoff, S. M. Harman, J. D. Veldhuis, J. J. Jayme, C. St. Clair, T. Munzer, C. Christmas, K. G. O'Connor, T. E. Stevens, M. F. Bellantoni, et al. Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men Am J Physiol Endocrinol Metab, April 1, 2001; 280(4): E616 - E625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Waters, C. R. Qualls, R. Dorin, J. D. Veldhuis, and R. N. Baumgartner Increased Pulsatility, Process Irregularity, and Nocturnal Trough Concentrations of Growth Hormone in Amenorrheic Compared to Eumenorrheic Athletes J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1013 - 1019. [Abstract] [Full Text]
|
|
|
|
|
|
M. G. Murphy, S. Weiss, M. McClung, T. Schnitzer, K. Cerchio, J. Connor, D. Krupa, and B. J. Gertz Effect of Alendronate and MK-677 (a Growth Hormone Secretagogue), Individually and in Combination, on Markers of Bone Turnover and Bone Mineral Density in Postmenopausal Osteoporotic Women J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1116 - 1125. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Veldhuis, M. Straume, A. Iranmanesh, T. Mulligan, C. Jaffe, A. Barkan, M. L. Johnson, and S. Pincus Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R721 - R729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rietschel, C. Hadigan, C. Corcoran, T. Stanley, G. Neubauer, J. Gertner, and S. Grinspoon Assessment of Growth Hormone Dynamics in Human Immunodeficiency Virus-Related Lipodystrophy J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 504 - 510. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Anderson, N. Shah, W. S. Evans, J. T. Patrie, C. Y. Bowers, and J. D. Veldhuis Short-Term Estradiol Supplementation Augments Growth Hormone (GH) Secretory Responsiveness to Dose-Varying GH-Releasing Peptide Infusions in Healthy Postmenopausal Women J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 551 - 560. [Abstract] [Full Text]
|
