| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 80, 3068-3072, Copyright © 1995 by Endocrine Society
ARTICLES |
B Dawson-Hughes, SS Harris, S Finneran and HM Rasmussen
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.
On the basis of recent findings that adult black women had similar calcium absorption but higher levels of 1,25-dihydroxyvitamin D [1,25- (OH)2D] than white women, we hypothesized that blacks have a gut resistance to the action of calcitriol. To test this, we studied 11 black [age, 32.4 +/- 5.7 (+/- SD) yr] and 12 white women (28.4 +/- 5.5 yr). The women were maintained on a constant 500-mg calcium diet for 4 weeks, and each received calcitriol (0.25 microgram) four times daily for the last 2 weeks. After 2 and 4 weeks, each subject had measurements of fractional 45Ca absorption index and blood and urine tests. At 2 weeks, the black women had similar calcium absorption indexes [18.7 +/- 1.9% (+/- SEM)/L vs. 20.0 +/- 1.8%/L; age adjusted], borderline higher 1,25-(OH)2D levels [95.7 +/- 6.4 (+/- SEM) vs. 78.2 +/- 6.2 pmol/L; P = 0.071; age adjusted], higher serum PTH levels, and lower urinary calcium excretion. Calcitriol therapy induced similar increments in plasma 1,25-(OH)2D levels in the two groups, but a smaller increment in calcium absorption in the black women (18.4 +/- 8.6% vs. 44.6 +/- 7.8%; P = 0.043; means adjusted for age and initial absorption index). These findings support the hypothesis that, compared with whites, healthy premenopausal black women have gut resistance to the action of calcitriol.
This article has been cited by other articles:
 |
|
 |
|
  L. H. Foo, Q. Zhang, K. Zhu, G. Ma, X. Hu, H. Greenfield, and D. R. Fraser Low Vitamin D Status Has an Adverse Influence on Bone Mass, Bone Turnover, and Muscle Strength in Chinese Adolescent Girls J. Nutr., May 1, 2009; 139(5): 1002 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P Reis, E. D Michos, D. von Muhlen, and E. R Miller III Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1469 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. N. Ibrahim, C. Wang, A. Ishani, A. J. Collins, and R. N. Foley Screening for Chronic Kidney Disease Complications in US Adults: Racial Implications of a Single GFR Threshold Clin. J. Am. Soc. Nephrol., November 1, 2008; 3(6): 1792 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fausto-Sterling The bare bones of race. Social Studies of Science, October 1, 2008; 38(5): 657 - 694. [Abstract] [PDF]
|
|
|
|
|
|
S. S. Harris Vitamin D and African Americans J. Nutr., April 1, 2006; 136(4): 1126 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dawson-Hughes Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1763S - 1766S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lips Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic Implications Endocr. Rev., August 1, 2001; 22(4): 477 - 501. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
