help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vikic-Topic, S.
Right arrow Articles by Vuk-Pavlovic, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vikic-Topic, S.
Right arrow Articles by Vuk-Pavlovic, S.

Journal of Clinical Endocrinology & Metabolism, Vol 80, 2974-2979, Copyright © 1995 by Endocrine Society

ARTICLES

Expression of somatostatin receptor subtypes in breast carcinoma, carcinoid tumor, and renal cell carcinoma

S Vikic-Topic, KP Raisch, LK Kvols and S Vuk-Pavlovic
Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.

The presence of transcripts for somatostatin receptor (SSTR) subtypes 1, 2, 3, and 4 was probed by reverse transcription and polymerase chain reaction in ribonucleic acid isolated from 46 malignant and 9 nonmalignant breast tissues, 15 carcinoid tumor tissues, and 13 renal cell carcinoma tissues. The transcripts for SSTR2 were amplified in all but 2 tissue samples, whereas transcripts for SSTR1, SSTR3, and SSTR4 were detected sporadically. In renal cell tumors, SSTR3 transcripts were completely absent. In breast cancer tissue, SSTR subtypes were transcribed independently of patient age, menstrual status, diagnosis, histological grade, and levels of estrogen receptor and progesterone receptor. The probability of finding transcripts for SSTR subtypes, P, was ranked differently for the three types of tumor tissues. For breast cancer, P2 > P3 = P1 > P4; for carcinoid tumors, P2 > P1 > P3 = P4; and for renal cell tumors, P2 > P1 > P4 > P3.


This article has been cited by other articles:


Home page
 JNMHome page
B. Van Den Bossche, S. Van Belle, F. De Winter, A. Signore, and C. Van de Wiele
Early Prediction of Endocrine Therapy Effect in Advanced Breast Cancer Patients Using 99mTc-Depreotide Scintigraphy
J. Nucl. Med., January 1, 2006; 47(1): 6 - 13.
[Abstract] [Full Text] [PDF]

Home page
 J. Nucl. Med. Technol.Home page
W.-J. Shih, R. A.L. Romero, M. Timothy, and P. P. Milan
99mTc-Depreotide Chest SPECT Demonstrates Pulmonary Metastases from Renal Cell Carcinoma
J. Nucl. Med. Technol., March 1, 2004; 32(1): 19 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. C. Reubi
Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy
Endocr. Rev., August 1, 2003; 24(4): 389 - 427.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. J. Hofland and S. W. J. Lamberts
The Pathophysiological Consequences of Somatostatin Receptor Internalization and Resistance
Endocr. Rev., February 1, 2003; 24(1): 28 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
J. T. Dolan, D. M. Miltenburg, T. S. Granchi, C. C. Miller, and F. C. Brunicardi
Treatment of Metastatic Breast Cancer With Somatostatin Analogues--A Meta-Analysis
Ann. Surg. Oncol., April 1, 2001; 8(3): 227 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. A. Balster, M. S. O'Dorisio, M. A. Summers, and M. A. Turman
Segmental expression of somatostatin receptor subtypes sst1 and sst2 in tubules and glomeruli of human kidney
Am J Physiol Renal Physiol, March 1, 2001; 280(3): F457 - F465.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. C. Reubi, B. Waser, Q. Liu, J. A. Laissue, and A. Schonbrunn
Subcellular Distribution of Somatostatin sst2A Receptors in Human Tumors of the Nervous and Neuroendocrine Systems: Membranous Versus Intracellular Location
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3882 - 3891.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
A. Plonowski, A. V. Schally, A. Nagy, H. Kiaris, F. Hebert, and G. Halmos
Inhibition of Metastatic Renal Cell Carcinomas Expressing Somatostatin Receptors by a Targeted Cytotoxic Analogue of Somatostatin AN-238
Cancer Res., June 1, 2000; 60(11): 2996 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. A. Sinisi, A. Bellastella, D. Prezioso, M. R. Nicchio, T. Lotti, M. Salvatore, and D. Pasquali
Different Expression Patterns of Somatostatin Receptor Subtypes in Cultured Epithelial Cells from Human Normal Prostate and Prostate Cancer
J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2566 - 2569.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. B. Ain, K. D. Taylor, S. Tofiq, and G. Venkataraman
Somatostatin Receptor Subtype Expression in Human Thyroid and Thyroid Carcinoma Cell Lines
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1857 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Benlot, L. Levy, P. Fontanaud, A. Roche, P. Rouannet, and D. Joubert
Somatostatin and Growth Hormone-Releasing Hormone in Normal and Tumoral Human Breast Tissue: Endogenous Content, in Vitro Pulsatile Release, and Regulation
J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 690 - 696.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1995 by The Endocrine Society