help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bianchetti, M. G.
Right arrow Articles by Jaeger, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bianchetti, M. G.
Right arrow Articles by Jaeger, P.

Journal of Clinical Endocrinology & Metabolism, Vol 80, 224-228, Copyright © 1995 by Endocrine Society

ARTICLES

Evidence for disturbed regulation of calciotropic hormone metabolism in gitelman syndrome

MG Bianchetti, A Bettinelli, JP Casez, E Basilico, MG Metta, I Spicher, C Santeramo, M Bigoni and P Jaeger
Abteilung fur Nephrologie, Universitatskinderklinik, Bern, Switzerland.

Little attention has been paid to interactions between circulating levels of calcium, PTH, and 1,25-dihydroxycholecalciferol [1,25(OH)2D] and bone mineral density in primary renal magnesium deficiency. Plasma and urinary electrolytes, and circulating levels of calciotropic hormones were studied in 13 untreated patients with primary renal tubular hypokalemic alkalosis with hypocalciuria and magnesium deficiency. The blood ionized calcium concentration was significantly lower in patients than in controls. Despite this fact, PTH and 1,25- (OH)2D levels were similar in both groups of subjects. The negative linear relationships between PTH and ionized calcium, which significantly differed between Gitelman patients and healthy subjects in terms of intercept; the negative relationship between ionized calcium and 1,25-(OH)2D, which was comparable in both groups; and the positive relationship between 1,25-(OH)2D and PTH, which was identical in both groups, point both to a blunted secretion of PTH induced by magnesium depletion and to the lack of interference of the latter with the activation of 1 alpha-hydroxylase by PTH. The similar bone mineral density at the lumbar spine by dual energy x-ray absorptiometry in 11 patients and 11 healthy subjects argues against chronically sustained negative calcium balance.


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. T. Barakat, H. Ashrafian, J. F. Todd, J. J. Boyle, J. A. Lynn, and G. R. Williams
Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism
Nephrol. Dial. Transplant., April 1, 2004; 19(4): 977 - 980.
[Full Text] [PDF]

Home page
 QJMHome page
I. Amirlak and K.P. Dawson
Bartter syndrome: an overview
QJM, April 1, 2000; 93(4): 207 - 215.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1995 by The Endocrine Society