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Journal of Clinical Endocrinology & Metabolism, Vol 79, 1852-1856, Copyright © 1994 by Endocrine Society

ARTICLES

Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma

E Grouzmann, P Werffeli-George, M Fathi, M Burnier, B Waeber and G Waeber
Division d'Hypertension, CHUV, Lausanne, Switzerland.

The potential role of angiotensin-II in mediating catecholamine and neuropeptide-Y release in a human pheochromocytoma has been investigated. Angiotensin-II type I receptors are transcribed and translated into functional proteins in a surgically removed pheochromocytoma. Primary cell culture of the tumor has been studied in a perfused system. Angiotensin-II increased the release of norepinephrine and neuropeptide-Y by the pheochromocytes. Activation of the angiotensin-II type I receptors by angiotensin-II was associated with a rise in cytosolic free calcium. The renin-angiotensin system may, therefore, contribute to the secretion of catecholamines and NPY occurring in patients with pheochromocytoma and when stimulated trigger hypertensive crisis.


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