help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sane, T.
Right arrow Articles by Pelkonen, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sane, T.
Right arrow Articles by Pelkonen, R.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH

Journal of Clinical Endocrinology & Metabolism, Vol 79, 1395-1398, Copyright © 1994 by Endocrine Society

ARTICLES

Hyponatremia after transsphenoidal surgery for pituitary tumors

T Sane, K Rantakari, A Poranen, R Tahtela, M Valimaki and R Pelkonen
Third Department of Medicine, University Hospital, Helsinki, Finland.

We studied the incidence of postoperative hyponatremia in 91 consecutive patients (44 males and 47 females; age, 45 yr; range, 12- 76) operated on transsphenoidally for pituitary tumors. A postoperative serum sodium concentration less than 135 mmol/L (the lowest, 109 mmol/L) was observed in 32 (35%) patients. Hyponatremia occurred most commonly in patients operated on for Cushing's disease (11 of 18 patients; 61%). Hyponatremia was symptomatic in 18 (56%) of the patients. Neither the size nor the operability of the tumor or transient postoperative polyuria predicted the development of hyponatremia. Hyponatremia was first observed on the sixth or seventh postoperative day. The patients were treated with water restriction and by increasing the hydrocortisone replacement dose in the case of ACTH deficiency, and recovery took place, on the average, within 5 days. High urinary osmolality and plasma arginine vasopressin concentration during hyponatremia in a subgroup of study patients with these measurements indicated that inappropriate vasopressin secretion was involved in the pathogenesis of hyponatremia. In conclusion, postoperative hyponatremia after transsphenoidal surgery is common and may put the patients at increased risk of severe hyponatremic symptoms. Therefore, all patients should be screened for serum electrolytes for 1 week after transsphenoidal surgery.


This article has been cited by other articles:


Home page
 Clin Med ResHome page
A. A. Onitilo, E. Kio, and S. A. R. Doi
Tumor-Related Hyponatremia
Clin. Med. Res., December 1, 2007; 5(4): 228 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
R Guerrero, A Pumar, A Soto, M A Pomares, S Palma, M A Mangas, A Leal, and F Villamil
Early hyponatraemia after pituitary surgery: cerebral salt-wasting syndrome
Eur. J. Endocrinol., June 1, 2007; 156(6): 611 - 616.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
A. S. Dumont, E. C. Nemergut II, J. A. Jane Jr, and E. R. Laws Jr
Postoperative Care Following Pituitary Surgery
J Intensive Care Med, May 1, 2005; 20(3): 127 - 140.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society