help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Combes-Moukhovsky, M. E.
Right arrow Articles by Attali, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Combes-Moukhovsky, M. E.
Right arrow Articles by Attali, J. R.

Journal of Clinical Endocrinology & Metabolism, Vol 79, 1390-1394, Copyright © 1994 by Endocrine Society

ARTICLES

Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumors and congenital adrenal hyperplasia

ME Combes-Moukhovsky, ML Kottler, P Valensi, P Boudou, M Sibony and JR Attali
Service d'Endocrinologie, Diabetologie et Nutrition, Hopital Jean Verdier, Bondy, France.

We report the case of a patient with bilateral testicular tumors and congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Catheterization of the left testicular and adrenal veins was performed. The presence of 11 beta-hydroxylated steroids in the spermatic veins confirmed the presence of testicular tumor secondary to adrenal rest cells. After adrenal suppression by dexamethasone combined with gonadal stimulation with hCG, a dramatic decrease in androgens and adrenal steroids was observed in the peripheral blood. Compared to the periphery, 21-deoxycortisol and 11 beta-hydroxy-delta 4-androstenedione levels remained higher than that of 21-deoxycorticosterone in the gonadal vein, but not in the adrenal vein, which seems to indicate that the nature of this ectopic tissue is unusual and that its sensitivity to dexamethasone depends on the adrenocortical zones. No rise in estradiol or testosterone was obtained after hCG stimulation, suggesting that all of the testicular tissue was inactive or destroyed. This finding was confirmed by histological examination.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
A. Martinez-Aguayo, A. Rocha, N. Rojas, C. Garcia, R. Parra, M. Lagos, L. Valdivia, H. Poggi, A. Cattani, and the Chilean Collaborative Testicular Adrenal Rest
Testicular Adrenal Rest Tumors and Leydig and Sertoli Cell Function in Boys with Classical Congenital Adrenal Hyperplasia
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4583 - 4589.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. L. Claahsen-van der Grinten, B. J. Otten, F. C. G. J. Sweep, P. N. Span, H. A. Ross, E. J. H. Meuleman, and A. R. M. M. Hermus
Testicular Tumors in Patients with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency Show Functional Features of Adrenocortical Tissue
J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3674 - 3680.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. L. Claahsen-van der Grinten, B. J. Otten, S. Takahashi, E. J. H. Meuleman, C. Hulsbergen-van de Kaa, F. C. G. J. Sweep, and A. R. M. M. Hermus
Testicular Adrenal Rest Tumors in Adult Males with Congenital Adrenal Hyperplasia: Evaluation of Pituitary-Gonadal Function before and after Successful Testis-Sparing Surgery in Eight Patients
J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 612 - 615.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Tiitinen and M. Valimaki
Primary Infertility in 45-Year-Old Man with Untreated 21-Hydroxylase Deficiency: Successful Outcome with Glucocorticoid Therapy
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2442 - 2445.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
D. P. Merke, S. R. Bornstein, N. A. Avila, and G. P. Chrousos
Future Directions in the Study and Management of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Ann Intern Med, February 19, 2002; 136(4): 320 - 334.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. M. M. L. Stikkelbroeck, B. J. Otten, A. Pasic, G. J. Jager, C. G. J. F. Sweep, K. Noordam, and A. R. M. M. Hermus
High Prevalence of Testicular Adrenal Rest Tumors, Impaired Spermatogenesis, and Leydig Cell Failure in Adolescent and Adult Males with Congenital Adrenal Hyperplasia
J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5721 - 5728.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. S. Cabrera, M. G. Vogiatzi, and M. I. New
Long Term Outcome in Adult Males with Classic Congenital Adrenal Hyperplasia
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3070 - 3078.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
G. Russo, P. Paesano, G. Taccagni, A. Del Maschio, and G. Chiumello
Ovarian Adrenal-Like Tissue in Congenital Adrenal Hyperplasia
N. Engl. J. Med., September 17, 1998; 339(12): 853 - 854.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society