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Journal of Clinical Endocrinology & Metabolism, Vol 79, 991-996, Copyright © 1994 by Endocrine Society

ARTICLES

The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides)

L Rhodes, J Harper, H Uno, G Gaito, J Audette-Arruda, S Kurata, C Berman, R Primka and B Pikounis
Merck Research Laboratories, Rahway, New Jersey 07065-0900.

Finasteride, a 5 alpha-reductase inhibitor, was administered orally (1 mg/kg.day) for 6 months to six male and five female stumptail macaques. Vehicle was given to five male and five female animals over the same period of time. Hair weights in a defined 1-in.2 area of frontal scalp were measured periodically every 1-2 months, and serum was collected for measurement of testosterone and dihydrotestosterone. In addition, scalp biopsies were taken before and 6 months after treatment to evaluate the micromorphometry of hair follicles. Results showed that both male and female serum dihydrotestosterone levels were significantly reduced (60-70%) by finasteride treatment. Both males and females showed statistically significant increases in mean hair weight over the treatment period compared to controls (P = 0.034). In addition, there was a statistically significant increase in mean follicle length (measured histologically in scalp biopsies) compared to baseline in the finasteride-treated animals (P = 0.028). These data show that an inhibition of 5 alpha-reductase in the stumptail macaque can reverse the balding seen with age in both the male and female animals.


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 Arch DermatolHome page
P. Boudou and P. Reygagne
Increased Scalp Skin and Serum 5{alpha}-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia
Arch Dermatol, September 1, 1997; 133(9): 1129 - 1133.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
N. Obana, C. Chang, and H. Uno
Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque
Endocrinology, January 1, 1997; 138(1): 356 - 361.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by The Endocrine Society