| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 79, 366-371, Copyright © 1994 by Endocrine Society
ARTICLES |
KM Prestwood, CC Pilbeam, JA Burleson, FN Woodiel, PD Delmas, LJ Deftos and LG Raisz
Travelers Center on Aging, University of Connecticut Health Center, Farmington 06030.
Estrogen replacement therapy (ERT) prevents bone loss and fracture in early postmenopausal women, but its benefit for women over 70 yr of age has not been determined. We have examined the effect of a short course of ERT on biochemical markers of bone turnover in older women. Eleven women (mean age, 77 yr) were given conjugated estrogen (Premarin; 0.625 mg/day) for 6 weeks. Biochemical markers were measured on serum and urine collected at baseline (two samples), after 5 and 6 weeks of ERT, and 5 and 6 weeks post-ERT. Markers of bone formation were osteocalcin, bone alkaline phosphatase, and type I procollagen peptide. Markers of bone resorption were total urinary hydroxyproline, total and free pyridinoline and deoxypyridinoline cross-links, type I collagen cross- linked N-telopeptides, and serum C-terminal cross-linked telopeptide. Data were analyzed by repeated measures multivariate analysis of variance to estimate the overall effect of ERT on the biochemical markers. Markers of bone resorption decreased during ERT and returned to baseline after ERT (P < 0.05). Markers of bone formation declined less during ERT and continued to decline after ERT (P < 0.05). We conclude that ERT reduces bone turnover in older women and that markers of bone turnover may be useful in assessing the response to treatment in this age group.
This article has been cited by other articles:
 |
|
 |
|
  D.B. Kimmel Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates J. Dent. Res., November 1, 2007; 86(11): 1022 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ueda, M. Inaba, K. Takada, J. Fukui, Y. Sakaguchi, M. Tsuda, M. Omae, T. Kushida, H. Iida, and S. Ikehara Induction of Senile Osteoporosis in Normal Mice by Intra-Bone Marrow-Bone Marrow Transplantation from Osteoporosis-Prone Mice Stem Cells, June 1, 2007; 25(6): 1356 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gardner, A. Taylor, G. Wei, A. Calcagni Jr, B. Duncan, and A. Milton Clinical Pharmacology of Multiple Doses of Lasofoxifene in Postmenopausal Women J. Clin. Pharmacol., January 1, 2006; 46(1): 52 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. Baron, M. P. Brincat, R. Galea, and N. Calleja Intervertebral disc height in treated and untreated overweight post-menopausal women Hum. Reprod., December 1, 2005; 20(12): 3566 - 3570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Prestwood, A. M. Kenny, A. Kleppinger, and M. Kulldorff Ultralow-Dose Micronized 17{beta}-Estradiol and Bone Density and Bone Metabolism in Older Women: A Randomized Controlled Trial JAMA, August 27, 2003; 290(8): 1042 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Finkelstein, M. Sowers, G. A. Greendale, M.-L. T. Lee, R. M. Neer, J. A. Cauley, and B. Ettinger Ethnic Variation in Bone Turnover in Pre- and Early Perimenopausal Women: Effects of Anthropometric and Lifestyle Factors J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3051 - 3056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Tobias, S. Clarke, K. Mitchell, S. Robins, H. Amer, and W. D. Fraser Analysis of the Contribution of Dydrogesterone to Bone Turnover Changes in Postmenopausal Women Commencing Hormone Replacement Therapy J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1194 - 1198. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Prestwood, A. M. Kenny, C. Unson, and M. Kulldorff The Effect of Low Dose Micronized 17{beta}-Estradiol on Bone Turnover, Sex Hormone Levels, and Side Effects in Older Women: A Randomized, Double Blind, Placebo-Controlled Study J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4462 - 4469. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Prestwood, M. Gunness, D. B. Muchmore, Y. Lu, M. Wong, and L. G. Raisz A Comparison of the Effects of Raloxifene and Estrogen on Bone in Postmenopausal Women J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2197 - 2202. [Abstract] [Full Text]
|
|
|
|
|
|
E. Baracat, M. Haidar, F. J. López, J. Pickar, M. Dey, and A. Negro-Vilar Estrogen Activity and Novel Tissue Selectivity of {Delta}8,9-Dehydroestrone Sulfate in Postmenopausal Women J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 2020 - 2027. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. W. Al-Dehaimi, A. Blumsohn, and R. Eastell Serum Galactosyl Hydroxylysine as a Biochemical Marker of Bone Resorption Clin. Chem., May 1, 1999; 45(5): 676 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Prestwood, D. L. Thompson, A. M. Kenny, M. J. Seibel, C. C. Pilbeam, and L. G. Raisz Low Dose Estrogen and Calcium Have an Additive Effect on Bone Resorption in Older Women J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 179 - 183. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. G. Raisz and K. M. Prestwood Estrogen and the Risk of Fracture -- New Data, New Questions N. Engl. J. Med., September 10, 1998; 339(11): 767 - 768. [Full Text]
|
|
|
|
|
|
S. Khosla, L. J. Melton III, E. J. Atkinson, W. M. O’Fallon, G. G. Klee, and B. L. Riggs Relationship of Serum Sex Steroid Levels and Bone Turnover Markers with Bone Mineral Density in Men and Women: A Key Role for Bioavailable Estrogen J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2266 - 2274. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. R. Tau, T. E. Hefferan, K. M. Waters, J. A. Robinson, M. Subramaniam, B. L. Riggs, and T. C. Spelsberg Estrogen Regulation of a Transforming Growth Factor-{beta} Inducible Early Gene That Inhibits Deoxyribonucleic Acid Synthesis in Human Osteoblasts Endocrinology, March 1, 1998; 139(3): 1346 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gorai, Y. Taguchi, O. Chaki, R. K. M. Nakayama, B. C. Yang, S. Yokota, and H. Minaguchi Serum Soluble Interleukin-6 Receptor and Biochemical Markers of Bone Metabolism Show Significant Variations During the Menstrual Cycle J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 326 - 332. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Clemens, M. V. Herrick, F. R. Singer, and D. R. Eyre Evidence that serum NTx (collagen-type I N-telopeptides) can act as an immunochemical marker of bone resorption Clin. Chem., November 1, 1997; 43(11): 2058 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Labrie, P. Diamond, L. Cusan, J.-L. Gomez, A. Belanger, and B. Candas Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3498 - 3505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. De Souza, B. E. Miller, L. C. Sequenzia, A. A. Luciano, S. Ulreich, S. Stier, K. Prestwood, and B. L. Lasley Bone Health Is Not Affected by Luteal Phase Abnormalities and Decreased Ovarian Progesterone Production in Female Runners J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 2867 - 2876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Heikkinen, M. Parviainen, L. Niskanen, M. Komulainen, M. T. Tuppurainen, H. Kroger, and S. Saarikoski Biochemical Bone Markers and Bone Mineral Density during Postmenopausal Hormone Replacement Therapy with and without Vitamin D3: A Prospective, Controlled, Randomized Study J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2476 - 2482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Luo, C. Labrie, A. Belanger, and F. Labrie Effect of Dehydroepiandrosterone on Bone Mass, Serum Lipids, and Dimethylbenz(a)anthracene-Induced Mammary Carcinoma in the Rat Endocrinology, August 1, 1997; 138(8): 3387 - 3394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Robinson, S. A. Harris, B. L. Riggs, and T. C. Spelsberg Estrogen Regulation of Human Osteoblastic Cell Proliferation and Differentiation Endocrinology, July 1, 1997; 138(7): 2919 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Khosla, E. J. Atkinson, L. J. Melton III, and B. L. Riggs Effects of Age and Estrogen Status on Serum Parathyroid Hormone Levels and Biochemical Markers of Bone Turnover in Women: A Population-Based Study J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1522 - 1527. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
