help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Woodworth, S. H.
Right arrow Articles by Ullrich, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woodworth, S. H.
Right arrow Articles by Ullrich, V.

Journal of Clinical Endocrinology & Metabolism, Vol 78, 1225-1231, Copyright © 1994 by Endocrine Society

ARTICLES

Eicosanoid biosynthetic enzymes in placental and decidual tissues from preeclamptic pregnancies: increased expression of thromboxane-A2 synthase gene

SH Woodworth, X Li, ZM Lei, CV Rao, MA Yussman, JA Spinnato 2nd, C Yokoyama, T Tanabe and V Ullrich
Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Kentucky 40292.

Preeclampsia is a disease of late pregnancy characterized by hypertension, edema, and proteinuria, in which vasoconstriction, platelet aggregation, and reduced uteroplacental blood flow contribute to preterm delivery, perinatal morbidity, and mortality. Increased thromboxane-A2 (TXA2) and/or decreased prostacyclin (PGI2) have been implicated as causative factors of this disease. The present studies investigated the expression of TXA2 synthase gene along with those of TXA2 receptors, PGI2 synthase, cyclooxygenase-1 (COX-1), and COX-2 in placental and decidual tissue from preeclamptic and normal pregnancies. In situ hybridization and immunocytochemistry showed that primarily trophoblast layer and decidual cells express TXA2 synthase, COX-1, and COX-2 enzymes. Immunocytochemistry for PGI2 synthase and in situ hybridization for TXA2 receptors showed similar results. Trophoblast layer and decidua from preeclamptic pregnancies contained a greater abundance of mRNA and protein of TXA2 synthase than the matched normal pregnancies. In summary, our findings suggest that an increased local expression of TXA2 synthase could be responsible for local and/or peripheral vascular changes in preeclampsia.


This article has been cited by other articles:


Home page
 FASEB J.Home page
S.-T. J. HUANG, K. C. T. VO, D. J. LYELL, G. H. FAESSEN, S. TULAC, R. TIBSHIRANI, A. J. GIACCIA, and L. C. GIUDICE
Developmental response to hypoxia
FASEB J, September 1, 2004; 18(12): 1348 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Kriston, R. C. Venuto, C. Baylis, and G. Losonczy
Hemodynamic and renal effects of U-46619, a TXA2/PGH2 analog, in late-pregnant rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R831 - R837.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. D. Johnson, Y. Sadovsky, C. Graham, E. Y. Anteby, K. L. Polakoski, X. Huang, and D. M. Nelson
The Expression and Activity of Prostaglandin H Synthase-2 Is Enhanced in Trophoblast from Women with Preeclampsia
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3059 - 3062.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society