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Journal of Clinical Endocrinology & Metabolism, Vol 78, 523-525, Copyright © 1994 by Endocrine Society

ARTICLES

A family pedigree exhibiting features of both multiple endocrine neoplasia type 1 and McCune-Albright syndromes

DJ O'Halloran and SM Shalet
Department of Endocrinology, Christie Hospital, Manchester, United Kingdom.

The multiple endocrine neoplasia (MEN) type 1 and McCune-Albright syndromes share many clinical and biochemical characteristics. This report documents for the first time the occurrence and natural history of the McCune-Albright syndrome in a female with a strong family history of MEN type 1. There may be a functional link between both of these conditions, and there is a need to look for G-protein mutations as a mechanism for disease in MEN type 1.


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