help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greenman, Y.
Right arrow Articles by Melmed, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greenman, Y.
Right arrow Articles by Melmed, S.

Journal of Clinical Endocrinology & Metabolism, Vol 78, 398-403, Copyright © 1994 by Endocrine Society

ARTICLES

Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors

Y Greenman and S Melmed
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048-1865.

The expression of two somatostatin receptor subtypes, SSTR1 and SSTR2, was studied in 27 pituitary tumors and 1 chronic lymphocytic leukemia pituitary infiltrate. Solution hybridization techniques were used for RNA analysis. SSTR1 and SSTR2 were, respectively, expressed in 3 of 7 and 9 of 10 GH-secreting tumors, 1 of 9 and 5 of 9 nonfunctioning tumors, 4 of 5 and 0 of 5 of prolactinomas, and 1 of 3 and 0 of 3 ACTH- secreting tumors. The chronic lymphocytic leukemia infiltrate expressed the SSTR2 subtype. No correlation was detected among tumor size, level of hormonal hypersecretion, and somatostatin receptor expression status. Two acromegalic patients who responded to octreotide therapy exclusively expressed the SSTR2 subtype in their tumors. The results indicate that two SSTR subtypes are heterogeneously expressed in different pituitary adenoma cell types.


This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
T. Florio, F. Barbieri, R. Spaziante, G. Zona, L. J Hofland, P. M van Koetsveld, R. A Feelders, G. K Stalla, M. Theodoropoulou, M. D Culler, et al.
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study
Endocr. Relat. Cancer, June 1, 2008; 15(2): 583 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A. Colao, M. Filippella, R. Pivonello, C. Di Somma, A. Faggiano, and G. Lombardi
Combined therapy of somatostatin analogues and dopamine agonists in the treatment of pituitary tumours
Eur. J. Endocrinol., April 1, 2007; 156(suppl_1): S57 - S63.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
G. F Taboada, R. M Luque, W. Bastos, R. F C Guimaraes, J. B Marcondes, L. M C Chimelli, R. Fontes, P. J P Mata, P. N. Filho, D. P Carvalho, et al.
Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas
Eur. J. Endocrinol., January 1, 2007; 156(1): 65 - 74.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. L. Batista, X. Zhang, R. Gejman, P. J. Ansell, Y. Zhou, S. A. Johnson, B. Swearingen, E. T. Hedley-Whyte, C. A. Stratakis, and A. Klibanski
The Effects of SOM230 on Cell Proliferation and Adrenocorticotropin Secretion in Human Corticotroph Pituitary Adenomas
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4482 - 4488.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. P. Gillam, M. E. Molitch, G. Lombardi, and A. Colao
Advances in the Treatment of Prolactinomas
Endocr. Rev., August 1, 2006; 27(5): 485 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
E Thodou, G Kontogeorgos, D Theodossiou, and M Pateraki
Mapping of somatostatin receptor types in GH or/and PRL producing pituitary adenomas.
J. Clin. Pathol., March 1, 2006; 59(3): 274 - 279.
[Abstract] [Full Text] [PDF]

Home page
 JRSMHome page
E. B Tirovola and J. S Malpas
Treatment with octreotide to suppress corticotropin secretion by a carcinoid tumour
J R Soc Med, November 1, 2005; 98(11): 516 - 516.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Filopanti, C. Ronchi, E. Ballare, S. Bondioni, A. G. Lania, M. Losa, S. Gelmini, A. Peri, C. Orlando, P. Beck-Peccoz, et al.
Analysis of Somatostatin Receptors 2 and 5 Polymorphisms in Patients with Acromegaly
J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4824 - 4828.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
L. J Hofland, J. van der Hoek, R. Feelders, M. O van Aken, P. M van Koetsveld, M. Waaijers, D. Sprij-Mooij, C. Bruns, G. Weckbecker, W. W de Herder, et al.
The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5
Eur. J. Endocrinol., April 1, 2005; 152(4): 645 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. D. Murray, K. Kim, S.-G. Ren, I. Lewis, G. Weckbecker, C. Bruns, and S. Melmed
The Novel Somatostatin Ligand (SOM230) Regulates Human and Rat Anterior Pituitary Hormone Secretion
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3027 - 3032.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. J. Hofland, J. van der Hoek, P. M. van Koetsveld, W. W. de Herder, M. Waaijers, D. Sprij-Mooij, C. Bruns, G. Weckbecker, R. Feelders, A.-J. van der Lely, et al.
The Novel Somatostatin Analog SOM230 Is a Potent Inhibitor of Hormone Release by Growth Hormone- and Prolactin-Secreting Pituitary Adenomas in Vitro
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1577 - 1585.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Yan, M. E. E. Jones, M. Hernandez, D. Liu, E. R. Simpson, and C. Chen
Functional Modification of Pituitary Somatotropes in the Aromatase Knockout Mouse and the Effect of Estrogen Replacement
Endocrinology, February 1, 2004; 145(2): 604 - 612.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S.-G. Ren, J. Taylor, J. Dong, R. Yu, M. D. Culler, and S. Melmed
Functional Association of Somatostatin Receptor Subtypes 2 and 5 in Inhibiting Human Growth Hormone Secretion
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4239 - 4245.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. C. Reubi
Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy
Endocr. Rev., August 1, 2003; 24(4): 389 - 427.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. J. Hofland and S. W. J. Lamberts
The Pathophysiological Consequences of Somatostatin Receptor Internalization and Resistance
Endocr. Rev., February 1, 2003; 24(1): 28 - 47.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A.-M. O'Carroll
Localization of Messenger Ribonucleic Acids for Somatostatin Receptor Subtypes (sstr1-5) in the Rat Adrenal Gland
J. Histochem. Cytochem., January 1, 2003; 51(1): 55 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
D. MORRIS and A. GROSSMAN
The Medical Management of Cushing's Syndrome
Ann. N.Y. Acad. Sci., September 1, 2002; 970(1): 119 - 133.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. U. Freda
Somatostatin Analogs in Acromegaly
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3013 - 3018.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. C. Danila, J. N. S. Haidar, X. Zhang, L. Katznelson, M. D. Culler, and A. Klibanski
Somatostatin Receptor-Specific Analogs: Effects on Cell Proliferation and Growth Hormone Secretion in Human Somatotroph Tumors
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 2976 - 2981.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Saveanu, G. Gunz, H. Dufour, P. Caron, F. Fina, L. Ouafik, M. D. Culler, J. P. Moreau, A. Enjalbert, and P. Jaquet
BIM-23244, a Somatostatin Receptor Subtype 2- and 5-Selective Analog with Enhanced Efficacy in Suppressing Growth Hormone (GH) from Octreotide-Resistant Human GH-Secreting Adenomas
J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 140 - 145.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Reubi, J.-C. Schaer, S. Wenger, C. Hoeger, J. Erchegyi, B. Waser, and J. Rivier
SST3-selective potent peptidic somatostatin receptor antagonists
PNAS, November 22, 2000; (2000) 250483897.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. C. Reubi, B. Waser, Q. Liu, J. A. Laissue, and A. Schonbrunn
Subcellular Distribution of Somatostatin sst2A Receptors in Human Tumors of the Nervous and Neuroendocrine Systems: Membranous Versus Intracellular Location
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3882 - 3891.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. Park, J. Kamegai, T. A. Johnson, L. A. Frohman, and R. D. Kineman
Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) Messenger Ribonucleic Acid Levels by Changes in the Growth Hormone Axis
Endocrinology, October 1, 2000; 141(10): 3556 - 3563.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Jaquet, A. Saveanu, G. Gunz, F. Fina, A. J. Zamora, M. Grino, M. D. Culler, J. P. Moreau, A. Enjalbert, and L'H. Ouafik
Human Somatostatin Receptor Subtypes in Acromegaly: Distinct Patterns of Messenger Ribonucleic Acid Expression and Hormone Suppression Identify Different Tumoral Phenotypes
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 781 - 792.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
H. Baumeister, M. Wegner, D. Richter, and W. Meyerhof
Dual Regulation Of Somatostatin Receptor Subtype 1 Gene Expression By Pit-1 In Anterior Pituitary GH3 Cells
Mol. Endocrinol., February 1, 2000; 14(2): 255 - 271.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Barlier, I. Pellegrini-Bouiller, G. Gunz, A. J. Zamora, P. Jaquet, and A. Enjalbert
Impact of gsp Oncogene on the Expression of Genes Coding for Gs{alpha}, Pit-1, Gi2{alpha}, and Somatostatin Receptor 2 in Human Somatotroph Adenomas: Involvement in Octreotide Sensitivity
J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2759 - 2765.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. H. D’Abronzo, B. Swearingen, A. Klibanski, and J. M. Alexander
Mutational Analysis of Activin/Transforming Growth Factor-{beta} Type I and Type II Receptor Kinases in Human Pituitary Tumors
J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1716 - 1721.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
A. Giustina and J. D. Veldhuis
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human
Endocr. Rev., December 1, 1998; 19(6): 717 - 797.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Nielsen, S. Mellemkjær, L. M. Rasmussen, T. Ledet, J. Astrup, J. Weeke, and J. O. L. Jørgensen
Gene Transcription of Receptors for Growth Hormone-Releasing Peptide and Somatostatin in Human Pituitary Adenomas
J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2997 - 3000.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
J. C. Reubi, A. Kappeler, B. Waser, J. Laissue, R. W. Hipkin, and A. Schonbrunn
Immunohistochemical Localization of Somatostatin Receptors sst2A in Human Tumors
Am. J. Pathol., July 1, 1998; 153(1): 233 - 245.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
J. EPELBAUM, N. BRIARD, D. DJORDJIJEVIC, A. DUTOUR, W. MEYERHOFF, C. OLIVER, A. SLAMA, C. VIOLLET, and J. ZHANG
Characterization of Somatostatin Receptor Subtypes in Mammalian Pituitary
Ann. N.Y. Acad. Sci., May 15, 1998; 839(1): 249 - 253.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. J. Hofland, W. W. de Herder, H. A. Visser-Wisselaar, C. van Uffelen, M. Waaijers, J. Zuyderwijk, P. Uitterlinden, M. J. M. Kros, P. M. van Koetsveld, and S. W. J. Lamberts
Dissociation between the Effects of Somatostatin (SS) and Octapeptide SS-Analogs on Hormone Release in a Small Subgroup of Pituitary- and Islet Cell Tumors
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3011 - 3018.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. Shimon and S. Melmed
Pituitary Tumor Pathogenesis
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1675 - 1681.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. B. Ain, K. D. Taylor, S. Tofiq, and G. Venkataraman
Somatostatin Receptor Subtype Expression in Human Thyroid and Thyroid Carcinoma Cell Lines
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1857 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. A. Visser-Wisselaar, C. J. C. van Uffelen, P. M. van Koetsveld, E. G. R. Lichtenauer-Kaligis, A. M. Waaijers, P. Uitterlinden, D. M. Mooy, S. W. J. Lamberts, and L. J. Hofland
17-{beta}-Estradiol-Dependent Regulation of Somatostatin Receptor Subtype Expression in the 7315b Prolactin Secreting Rat Pituitary Tumor in Vitro and in Vivo
Endocrinology, March 1, 1997; 138(3): 1180 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. A. James, V. D. Sarapura, C. Bruns, F. Raulf, J. M. Dowding, D. F. Gordon, W. M. Wood, and E. C. Ridgway
Thyroid Hormone-Induced Expression of Specific Somatostatin Receptor Subtypes Correlates with Involution of the TtT-97 Murine Thyrotrope Tumor
Endocrinology, February 1, 1997; 138(2): 719 - 724.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. W.J. Lamberts, A.-J. van der Lely, W. W. de Herder, and L. J. Hofland
Octreotide
N. Engl. J. Med., January 25, 1996; 334(4): 246 - 254.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Reubi, J.-C. Schaer, S. Wenger, C. Hoeger, J. Erchegyi, B. Waser, and J. Rivier
SST3-selective potent peptidic somatostatin receptor antagonists
PNAS, December 5, 2000; 97(25): 13973 - 13978.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society