Journal of Clinical Endocrinology & Metabolism, Vol 78, 310-312, Copyright © 1994 by Endocrine Society

ARTICLES

Insulin-like growth factor-I comparisons in healthy twin children

PC Kao, AP Matheny Jr and CA Lang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.

Insulin-like growth factor-I (IGF-I) levels in plasma were measured in healthy twin children. The within-pair correlation for 43 monozygotic pairs was r = 0.91 (P < or = 0.0001), an association significantly higher than that for same sex dizygotic pairs (r = 0.40; P < or = 0.06). The high correlation for monozygotic twins indicated a marked genetic influence on IGF-I levels. After correction for age and sex, the correlation between IGF-I level and height was r = 0.38 (P < or = 0.0001). These findings provide clear evidence that IGF-I levels correlate with height, a growth characteristic known to be genetically controlled.

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