help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barbot, N.
Right arrow Articles by Bigorgne, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barbot, N.
Right arrow Articles by Bigorgne, J. C.

Journal of Clinical Endocrinology & Metabolism, Vol 78, 114-120, Copyright © 1994 by Endocrine Society

ARTICLES

Pentagastrin stimulation test and early diagnosis of medullary thyroid carcinoma using an immunoradiometric assay of calcitonin: comparison with genetic screening in hereditary medullary thyroid carcinoma

N Barbot, C Calmettes, I Schuffenecker, JP Saint-Andre, B Franc, V Rohmer, P Jallet and JC Bigorgne
Service d'Endocrinologie, Centre Hospitalier Universitaire, Angers, France.

A pentagastrin stimulation test using a calcitonin (CT) immunoradiometric assay was performed in 38 healthy subjects and in the following 50 patients: 25 subjects from families with at least 2 known cases of medullary thyroid carcinoma (MTC), 11 subjects from families with apparently sporadic MTC, 2 pheochromocytoma carriers, 1 primary hyperparathyroidism, 8 patients with thyroid nodules, and 3 others with various diseases. In healthy volunteers, basal CT values were always less than 10 ng/L; the response to pentagastrin was below 30 ng/L for 36, and for the remaining 2, the peaks reached 30 for 1 subject and 48 ng/L for the other. The pentagastrin-stimulated CT peak was above 30 ng/L in each of the patients presented here, and all were thyroidectomized. In screening the 25 relatives of patients with familial MTC, a CT peak level over 30 ng/L was constantly associated with C-cell disease (23 cases of MTC and 2 of C-cell hyperplasia). A response to pentagastrin above 100 ng/L was observed in 15 patients among the 23 with MTC. In 8 of the 10 patients with a peak CT level between 30-100 ng/L, pathological examination showed a MTC; the other 2 had C-cell hyperplasia and a negative linkage study analysis. In the 25 other patients in the study without familial MTC, the pentagastrin- stimulated CT level was over 100 ng/L in 11 of the 14 subjects with MTC. The abnormal CT response to pentagastrin, which has been used as a criterion for surgical treatment, is currently determined by an immunoradiometric assay. Our study confirms that subjects with a peak CT level above 100 ng/L should undergo surgery whatever the reason for the test. In the context of inherited MTC, our results suggest that for patients with a CT peak level between 30-100 ng/L, surgery may actually be postponed when their probability of being gene carriers is low. Recent progress with the characterization of specific mutations in affected individuals will make familial screening much easier in the next few months.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
S. M. Baumgartner-Parzer, R. Lang, L. Wagner, G. Heinze, B. Niederle, K. Kaserer, W. Waldhausl, and H. Vierhapper
Polymorphisms in Exon 13 and Intron 14 of the RET Protooncogene: Genetic Modifiers of Medullary Thyroid Carcinoma?
J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6232 - 6236.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Karanikas, A. Moameni, C. Poetzi, G. Zettinig, K. Kaserer, C. Bieglmayer, B. Niederle, R. Dudczak, and C. Pirich
Frequency and Relevance of Elevated Calcitonin Levels in Patients with Neoplastic and Nonneoplastic Thyroid Disease and in Healthy Subjects
J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 515 - 519.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
G. Szinnai, C. Meier, P. Komminoth, and U. W. Zumsteg
Review of Multiple Endocrine Neoplasia Type 2A in Children: Therapeutic Results of Early Thyroidectomy and Prognostic Value of Codon Analysis
Pediatrics, February 1, 2003; 111(2): e132 - 139.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
G. Vitale, A. Ciccarelli, M. Caraglia, M. Galderisi, R. Rossi, S. Del Prete, A. Abbruzzese, and G. Lupoli
Comparison of Two Provocative Tests for Calcitonin in Medullary Thyroid Carcinoma: Omeprazole vs Pentagastrin
Clin. Chem., September 1, 2002; 48(9): 1505 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Lombardo, E. Baudin, E. Chiefari, F. Arturi, S. Bardet, B. Caillou, C. Conte, B. Dallapiccola, D. Giuffrida, J.-M. Bidart, et al.
Familial Medullary Thyroid Carcinoma: Clinical Variability and Low Aggressiveness Associated with RET Mutation at Codon 804
J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1674 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Engelbach, R. Görges, T. Forst, A. Pfützner, R. Dawood, S. Heerdt, T. Kunt, A. Bockisch, and J. Beyer
Improved Diagnostic Methods in the Follow-Up of Medullary Thyroid Carcinoma by Highly Specific Calcitonin Measurements
J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1890 - 1894.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
G. R. Mundy and T. A. Guise
Hormonal Control of Calcium Homeostasis
Clin. Chem., August 1, 1999; 45(8): 1347 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Pigny, C. Bauters, J.-L. Wemeau, M. Lecomte Houcke, M. Crepin, P. Caron, S. Giraud, A. Calender, M.-P. Buisine, J.-P. Kerckaert, et al.
A Novel 9-Base Pair Duplication in RET Exon 8 in Familial Medullary Thyroid Carcinoma
J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1700 - 1704.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
T. A. Guise and G. R. Mundy
Cancer and Bone
Endocr. Rev., February 1, 1998; 19(1): 18 - 54.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Vierhapper, W. Raber, C. Bieglmayer, K. Kaserer, A. Weinhausl, and B. Niederle
Routine Measurement of Plasma Calcitonin in Nodular Thyroid Diseases
J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1589 - 1593.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. F. Erdogan, S. Gullu, N. Baskal, A. R. Uysal, N. Kamel, and G. i Erdogan
Omeprazole: Calcitonin Stimulation Test for the Diagnosis Follow-Up and Family Screening in Medullary Thyroid Carcinoma
J. Clin. Endocrinol. Metab., March 1, 1997; 82(3): 897 - 899.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Niccoli, N. Wion-Barbot, P. Caron, J.-F. Henry, C. de Micco, J.-P. Saint Andre, J.-C. Bigorgne, E. Modigliani, and B. Conte-Devolx
Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients
J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 338 - 341.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Guyetant, M.-C. Rousselet, M. Durigon, D. Chappard, B. Franc, O. Guerin, and J.-P. Saint-Andre
Sex-Related C Cell Hyperplasia in the Normal Human Thyroid: A Quantitative Autopsy Study
J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 42 - 47.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society