Racial differences in aldosterone excretion: a longitudinal study in children
JH Pratt, AK Manatunga, LJ Bloem and W Li
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
Aldosterone production, estimated from urinary excretion of aldosterone and
the plasma aldosterone level, was found in a previous cross- sectional
study to be lower in black children than white children. The present study
examined aldosterone excretion longitudinally to determine whether the
aldosterone excretion rate changed with time and if the racial difference
in aldosterone excretion persisted. Urine samples were collected every 6
months for up to 5.5 yr in 351 white and 170 black children for
measurements of aldosterone, sodium (Na+), and potassium (K+) excretion.
Results were expressed per mumol urinary creatinine. Mean values for
excretion rates for the total longitudinal period were determined. Na+
excretion was not significantly different in the two groups, whereas K+
excretion was 18% lower in blacks than whites (P = 0.0001). Body weight and
urinary Na+ and K+ excretion were significantly related to aldosterone
excretion. After adjusting for these variables, the aldosterone excretion
rate was 35% lower in blacks than whites (P = 0.0001), a racial difference
that did not change with age. Aldosterone excretion rates showed no
longitudinal trend to either increase or decrease. The physiological
relevance of the lower aldosterone excretion rate in black children remains
unknown.
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