| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 76, 404-410, Copyright © 1993 by Endocrine Society
ARTICLES |
DJ Dudley, MS Trautman and MD Mitchell
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132.
The physiology of parturition, and the pathophysiology of preterm labor, is incompletely understood. Infection of gestational tissues may account for a significant proportion of women who experience preterm labor. Interleukin-8 (IL-8), or neutrophil-activating protein (NAP-1), is a potent chemotactic and activating factor for neutrophils and has been implicated in the pathogenesis of inflammatory injury to skin and lung, but has yet to be described in gestational tissues. Cultured chorion and decidual cells obtained from normal human pregnancies were used to evaluate whether these tissues produce IL-8 basally and in response to inflammatory cytokines. As measured by specific IL-8 RIA, chorion and decidual cells produce IL-8 constitutively and in response to IL-1 beta and tumor necrosis factor. Cotreatment of chorion cells or decidual cells with IL-1 beta and actinomycin D or cycloheximide abrogated IL-8 production. Northern blot analysis confirmed that IL-1 beta stimulation of chorion and decidual cells resulted in increased IL- 8 messenger RNA expression. Our data support the concept that a complex cytokine network between maternal and fetal gestational tissues exists, and that activation of inflammatory cytokine production in these tissues, including IL-8, likely contributes to the pathophysiology of infection-induced preterm labor.
This article has been cited by other articles:
 |
|
 |
|
  C. E. Kendal-Wright Stretching, Mechanotransduction, and Proinflammatory Cytokines in the Fetal Membranes Reproductive Sciences, December 1, 2007; 14(8_suppl): 35 - 41. [Abstract] [PDF]
|
|
|
|
 |
|
 Y.-Y. He, M.-R. Du, P.-F. Guo, X.-J. He, W.-h. Zhou, X.-Y. Zhu, and D.-J. Li Regulation of C-C motif chemokine ligand 2 and its receptor in human decidual stromal cells by pregnancy-associated hormones in early gestation Hum. Reprod., October 1, 2007; 22(10): 2733 - 2742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Lockwood, F. Arcuri, P. Toti, C. D. Felice, G. Krikun, S. Guller, L. F. Buchwalder, and F. Schatz Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Regulate Interleukin-8 Expression in Third Trimester Decidual Cells: Implications for the Genesis of Chorioamnionitis Am. J. Pathol., October 1, 2006; 169(4): 1294 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.J. Cahill, S. Tan, G. Dougan, P. O'Gaora, D. Pickard, N. Kennea, M.H.F. Sullivan, R.G. Feldman, and A.D. Edwards Universal DNA primers amplify bacterial DNA from human fetal membranes and link Fusobacterium nucleatum with prolonged preterm membrane rupture Mol. Hum. Reprod., October 1, 2005; 11(10): 761 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Zaga, G. Estrada-Gutierrez, J. Beltran-Montoya, R. Maida-Claros, R. Lopez-Vancell, and F. Vadillo-Ortega Secretions of Interleukin-1{beta} and Tumor Necrosis Factor {alpha} by Whole Fetal Membranes Depend on Initial Interactions of Amnion or Choriodecidua with Lipopolysaccharides or Group B Streptococci Biol Reprod, October 1, 2004; 71(4): 1296 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mulayim, S. F. Palter, U. A. Kayisli, L. Senturk, and A. Arici Chemokine Receptor Expression in Human Endometrium Biol Reprod, May 1, 2003; 68(5): 1491 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Caballero-Campo, F. Dominguez, J. Coloma, M. Meseguer, J. Remohi, A. Pellicer, and C. Simon Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation Mol. Hum. Reprod., April 1, 2002; 8(4): 375 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.H.F. Sullivan, S.A. Alvi, N.L. Brown, M.G. Elder, and P.R. Bennett The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E2 and interleukin-1{beta} from human fetal membranes Mol. Hum. Reprod., March 1, 2002; 8(3): 281 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Garcia-Pacheco, C. Oliver, M. Kimatrai, F. J. Blanco, and E. G. Olivares Human decidual stromal cells express CD34 and STRO-1 and are related to bone marrow stromal precursors Mol. Hum. Reprod., December 1, 2001; 7(12): 1151 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Runesson, K. Ivarsson, P. Olof Janson, and M. Brännström Gonadotropin- and Cytokine-Regulated Expression of the Chemokine Interleukin 8 in the Human Preovulatory Follicle of the Menstrual Cycle J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4387 - 4395. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. R.G. Challis, S. G. Matthews, W. Gibb, and S. J. Lye Endocrine and Paracrine Regulation of Birth at Term and Preterm Endocr. Rev., October 1, 2000; 21(5): 514 - 550. [Abstract] [Full Text]
|
|
|
|
|
|
S. Potter, M.D. Mitchell, W.R. Hansen, and K.W. Marvin NF-IL6 and CRE elements principally account for both basal and interleukin-1{beta}-induced transcriptional activity of the proximal 528 bp of the PGHS-2 promoter in amnion-derived AV3 cells: evidence for involvement of C/EBP{beta} Mol. Hum. Reprod., September 1, 2000; 6(9): 771 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Sennstrom, G. Ekman, G. Westergren-Thorsson, A. Malmstrom, B. Bystrom, U. Endresen, N. Mlambo, M. Norman, B. Stabi, and A. Brauner Human cervical ripening, an inflammatory process mediated by cytokines Mol. Hum. Reprod., April 1, 2000; 6(4): 375 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawano, H. Narahara, and J. M. Johnston Inhibitory Effect of Interleukin-8 on the Secretion of Platelet-Activating Factor Acetylhydrolase by Human Decidual Macrophages Reproductive Sciences, November 1, 1999; 6(6): 328 - 332. [Abstract] [PDF]
|
|
|
|
|
|
K. Nasu, H. Narahara, N. Matsui, Y. Kawano, Y. Tanaka, and I. Miyakawa Platelet-activating factor stimulates cytokine production by human endometrial stromal cells Mol. Hum. Reprod., June 1, 1999; 5(6): 548 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Oliver, M.J. Montes, J.A. Galindo, C. Ruiz, and E.G. Olivares Human decidual stromal cells express {alpha}-smooth muscle actin and show ultrastructural similarities with myofibroblasts Hum. Reprod., June 1, 1999; 14(6): 1599 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nasu, T. Sugano, N. Matsui, H. Narahara, Y. Kawano, and I. Miyakawa Expression of Hepatocyte Growth Factor in Cultured Human Endometrial Stromal Cells Is Induced through a Protein Kinase C-Dependent Pathway Biol Reprod, May 1, 1999; 60(5): 1183 - 1187. [Abstract] [Full Text]
|
|
|
|
|
|
S. Khatun, N. Kanayama, H. M. Belayet, M. Yonezawa, T. Kobayashi, and T. Terao Interleukin-8 potentiates the effect of interleukin-1-induced uterine contractions Hum. Reprod., February 1, 1999; 14(2): 560 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Dudley, D. Collmer, M. D. Mitchell, and M. S. Trautman Inflammatory Cytokine mRNA in Human Gestational Tissues: Implications for Term and Preterm Labor Reproductive Sciences, November 1, 1996; 3(6): 328 - 335. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Dudley, S. S. Edwin, and M. D. Mitchell Macrophage Inflammatory Protein-1{alpha} Regulates Prostaglandin E2 and Interleukin-6 Production by Human Gestational Tissues In Vitro Reproductive Sciences, January 1, 1996; 3(1): 12 - 16. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
