Inflammatory mediators regulate interleukin-8 production by cultured gestational tissues: evidence for a cytokine network at the chorio- decidual interface
DJ Dudley, MS Trautman and MD Mitchell
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132.
The physiology of parturition, and the pathophysiology of preterm labor, is
incompletely understood. Infection of gestational tissues may account for a
significant proportion of women who experience preterm labor. Interleukin-8
(IL-8), or neutrophil-activating protein (NAP-1), is a potent chemotactic
and activating factor for neutrophils and has been implicated in the
pathogenesis of inflammatory injury to skin and lung, but has yet to be
described in gestational tissues. Cultured chorion and decidual cells
obtained from normal human pregnancies were used to evaluate whether these
tissues produce IL-8 basally and in response to inflammatory cytokines. As
measured by specific IL-8 RIA, chorion and decidual cells produce IL-8
constitutively and in response to IL-1 beta and tumor necrosis factor.
Cotreatment of chorion cells or decidual cells with IL-1 beta and
actinomycin D or cycloheximide abrogated IL-8 production. Northern blot
analysis confirmed that IL-1 beta stimulation of chorion and decidual cells
resulted in increased IL- 8 messenger RNA expression. Our data support the
concept that a complex cytokine network between maternal and fetal
gestational tissues exists, and that activation of inflammatory cytokine
production in these tissues, including IL-8, likely contributes to the
pathophysiology of infection-induced preterm labor.
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