help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pekary, A. E.
Right arrow Articles by Hershman, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pekary, A. E.
Right arrow Articles by Hershman, J. M.

Journal of Clinical Endocrinology & Metabolism, Vol 76, 70-74, Copyright © 1993 by Endocrine Society

ARTICLES

Increased in vitro thyrotropic activity of partially sialated human chorionic gonadotropin extracted from hydatidiform moles of patients with hyperthyroidism

AE Pekary, IM Jackson, TM Goodwin, XP Pang, MD Hein and JM Hershman
Endocrinology Research Laboratory, West Los Angeles Veterans Administration Medical Center, Wadsworth Division, California 90073.

The intrinsic thyrotropic activity of hCG purified from normal pregnancy urine has been demonstrated in several laboratories. hCG has a specific thyrotropic potency of about 0.04-0.5 microU bovine (b) TSH/IU hCG, depending on the bioassay system. The corresponding potency for hCG derived from pathological sources, such as hydatidiform moles and choriocarcinoma tissue, or from the serum of these patients has not been studied as extensively. Since the biological activity of glycoproteins can be strongly influenced by variations in the oligosaccharide side-chain composition, we have investigated the effect of anion exchange chromatography on the thyrotropic potency of hCG derived from the hydatidiform mole and serum of three hyperthyroid patients with molar pregnancy. The activity for the fraction of total molar hCG immunoreactivity that was not retained by an anion exchange column (0.18-0.90 microM bTSH/IU hCG) was about twice that of the corresponding serum and molar hCG fraction eluting during the NaCl gradient elution (0.08-0.40 microU bTSH/IU hCG). The unretained hCG fraction corresponds to a previously described hCG precursor that is partially desialated in the C-terminal region of the beta-subunit.


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
P. Rodien, N. Jordan, A. Lefevre, J. Royer, C. Vasseur, F. Savagner, A. Bourdelot, and V. Rohmer
Abnormal stimulation of the thyrotrophin receptor during gestation
Hum. Reprod. Update, March 1, 2004; 10(2): 95 - 105.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
R GAMA
Hyperthyroidism induced by {beta}-human chorionic gonadotrophin
Postgrad. Med. J., June 1, 2001; 77(908): 423a - 423.
[Full Text]

Home page
 Arch Pediatr Adolesc MedHome page
J. C. Sanchez and J. E. Sanchez
Pathological Case of the Month
Arch Pediatr Adolesc Med, August 1, 1998; 152(8): 827 - 828.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. Glinoer
The Regulation of Thyroid Function in Pregnancy: Pathways of Endocrine Adaptation from Physiology to Pathology
Endocr. Rev., June 1, 1997; 18(3): 404 - 433.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1993 by The Endocrine Society