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Journal of Clinical Endocrinology & Metabolism, Vol 76, 127-133, Copyright © 1993 by Endocrine Society

ARTICLES

Autocrine stimulation of interleukin-1 in the growth of human thyroid carcinoma cell line NIM 1

K Zeki, Y Nakano, N Inokuchi, K Watanabe, I Morimoto, U Yamashita and S Eto
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

We reported first in this study that human thyroid cell line NIM 1 established from a patient with papillary adenocarcinoma of the thyroid associated with hypercalcemia and peripheral neutrocytosis produced interleukin (IL)-1 alpha and IL-1 beta in the culture supernatant and cell lysate as detected by murine thymocyte proliferative response and enzyme-linked immunosorbent assay. Production of IL-1 alpha and IL-1 beta was further confirmed by the demonstration of IL-1 alpha and IL-1 beta messenger ribonucleic acid expression with Northern blot hybridization analysis. The in vitro growth of NIM 1 cells was inhibited by the addition of anti-IL-1 alpha and IL-1 beta antibody. The growth of NIM 1 cells was further enhanced by the addition of recombinant human IL-1 alpha and IL-1 beta, whereas this enhancement was also inhibited by the addition of anti-IL-1 antibody. IL-1 receptors were expressed on NIM 1 cells. These results suggest that IL- 1 plays a regulatory role in the growth of NIM 1 cells by an autocrine mechanism.


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