help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parker, C. R.
Right arrow Articles by Carden, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parker, C. R., Jr
Right arrow Articles by Carden, L.

Journal of Clinical Endocrinology & Metabolism, Vol 75, 1519-1521, Copyright © 1992 by Endocrine Society

ARTICLES

Adrenocorticotropin interferes with transforming growth factor-beta- induced growth inhibition of neocortical cells from the human fetal adrenal gland

CR Parker Jr, AK Stankovic, C Harlin and L Carden
Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.

The effects of transforming growth factor-beta (TGF-beta) and ACTH on growth, as indicated by [3H]thymidine incorporation into DNA, of primary cultures of neocortical cells from the human fetal adrenal gland were studied. TGF-beta inhibited, in a dose- and time-dependent manner, the growth of fetal neocortical cells, and ACTH significantly blunted the inhibitory effects of TGF-beta on growth of these cells. ACTH did not block the inhibitory effects of TGF-beta on growth of fetal adrenal fibroblasts or liver cells; neither ACTH nor TGF-beta had any effect on growth of fetal kidney cells. Thus, it appears that growth regulation of the neocortex may differ strikingly from that of the fetal zone of the human fetal adrenal, in which ACTH and TGF-beta have been reported recently to have additive inhibitory effects on cell proliferation.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
B. Ragazzon, L. Cazabat, M. Rizk-Rabin, G. Assie, L. Groussin, H. Fierrard, K. Perlemoine, A. Martinez, and J. Bertherat
Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGF{beta}-Stimulated Apoptosis in Adrenocortical Cells
Cancer Res., September 15, 2009; 69(18): 7278 - 7284.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. C. Zatelli, R. Rossi, and E. C. degli Uberti
Androgen Influences Transforming Growth Factor-{beta}1 Gene Expression in Human Adrenocortical Cells
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 847 - 852.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
M. Ehrhart-Bornstein, J. P. Hinson, S. R. Bornstein, W. A. Scherbaum, and G. P. Vinson
Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis
Endocr. Rev., April 1, 1998; 19(2): 101 - 143.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
S. Mesiano and R. B. Jaffe
Developmental and Functional Biology of the Primate Fetal Adrenal Cortex
Endocr. Rev., June 1, 1997; 18(3): 378 - 403.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1992 by The Endocrine Society