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Journal of Clinical Endocrinology & Metabolism, Vol 75, 1519-1521, Copyright © 1992 by Endocrine Society

ARTICLES

Adrenocorticotropin interferes with transforming growth factor-beta- induced growth inhibition of neocortical cells from the human fetal adrenal gland

CR Parker Jr, AK Stankovic, C Harlin and L Carden
Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.

The effects of transforming growth factor-beta (TGF-beta) and ACTH on growth, as indicated by [3H]thymidine incorporation into DNA, of primary cultures of neocortical cells from the human fetal adrenal gland were studied. TGF-beta inhibited, in a dose- and time-dependent manner, the growth of fetal neocortical cells, and ACTH significantly blunted the inhibitory effects of TGF-beta on growth of these cells. ACTH did not block the inhibitory effects of TGF-beta on growth of fetal adrenal fibroblasts or liver cells; neither ACTH nor TGF-beta had any effect on growth of fetal kidney cells. Thus, it appears that growth regulation of the neocortex may differ strikingly from that of the fetal zone of the human fetal adrenal, in which ACTH and TGF-beta have been reported recently to have additive inhibitory effects on cell proliferation.


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