Journal of Clinical Endocrinology & Metabolism, Vol 74, 1405-1409, Copyright © 1992 by Endocrine Society

ARTICLES

Oxyntomodulin-like immunoreactivity: diurnal profile of a new potential enterogastrone

A Le Quellec, A Kervran, P Blache, AJ Ciurana and D Bataille
Service de Medecine Interne A, Hopital Saint-Eloi, Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France.

The biological specificity of oxyntomodulin toward the gastric mucosa results from its C-terminal octapeptide. A RIA using a specific antibody raised against this region permitted quantification of the whole set of proglucagon-derived peptides that interact with the oxyntomodulin recognition systems, corresponding to the new concept of oxyntomodulin-like-immunoreactivity (OLI). The present report describes the physiological 24-h OLI profile in human plasma (eight men and eight women; mean age, 45 yr; range, 20-77 yr). Blood was withdrawn every hour from 0700-1900 h and every 2 h from 2100-0500 h. A meal-dependent profile was found for circulating OLI, with basal values (60 +/- 7 ng/L) at 0500 h and rises elicited by each food intake. The highest value (136 +/- 21 ng/L) was obtained at 2100 h. Plasma concentrations and diurnal variations of OLI were similar to those of the other intestinal peptides known to exert an endocrine function. The mean circulating OLI values increased with age, whereas no change was noticed according to sex. The inhibitory effect exerted by the peptides of the OLI family on gastric acid secretion, the meal dependence of their plasma concentrations, and the observed synchronism of their diurnal profile with that previously described for somatostatin make them candidates for an enterogastrone action.

This article has been cited by other articles:

				E. T. Parlevliet, A. C. Heijboer, J. P. Schroder-van der Elst, L. M. Havekes, J. A. Romijn, H. Pijl, and E. P. M. Corssmit Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E142 - E147. [Abstract] [Full Text] [PDF]

				S. Stanley, K. Wynne, B. McGowan, and S. Bloom Hormonal Regulation of Food Intake Physiol Rev, October 1, 2005; 85(4): 1131 - 1158. [Abstract] [Full Text] [PDF]

				K. Wynne, S. Stanley, B. McGowan, and S. Bloom Appetite control J. Endocrinol., February 1, 2005; 184(2): 291 - 318. [Abstract] [Full Text] [PDF]

				M. A. Cohen, S. M. Ellis, C. W. Le Roux, R. L. Batterham, A. Park, M. Patterson, G. S. Frost, M. A. Ghatei, and S. R. Bloom Oxyntomodulin Suppresses Appetite and Reduces Food Intake in Humans J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4696 - 4701. [Abstract] [Full Text] [PDF]

				T. Piche, F. Zerbib, S. B. D. Varannes, C. Cherbut, Y. Anini, C. Roze, A. le Quellec, and J.-P. Galmiche Modulation by colonic fermentation of LES function in humans Am J Physiol Gastrointest Liver Physiol, April 1, 2000; 278(4): G578 - G584. [Abstract] [Full Text] [PDF]

				R. Geneviève, R. Magous, T. Mochizuki, D. Le Nguyen, J. Martinez, J.-P. Bali, D. Bataille, and C. Jarrousse Glicentin and Oxyntomodulin Modulate Both the Phosphoinositide and Cyclic Adenosine Monophosphate Signaling Pathways in Gastric Myocytes Endocrinology, January 1, 1999; 140(1): 22 - 28. [Abstract] [Full Text]