help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pacini, F.
Right arrow Articles by Pinchera, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pacini, F.
Right arrow Articles by Pinchera, A.

Journal of Clinical Endocrinology & Metabolism, Vol 74, 1401-1404, Copyright © 1992 by Endocrine Society

ARTICLES

Detection of thyroglobulin in fine needle aspirates of nonthyroidal neck masses: a clue to the diagnosis of metastatic differentiated thyroid cancer

F Pacini, L Fugazzola, F Lippi, C Ceccarelli, R Centoni, P Miccoli, R Elisei and A Pinchera
Istituto di Endocrinologia, University of Pisa, Italy.

We studied the feasibility of employing the measurement of thyroglobulin (Tg) in the washout of the needle used to perform the fine needle aspiration cytology (FNA-Tg) for the differential diagnosis of nonthyroidal neck masses of unknown etiology. We studied 35 patients presenting for 1 or more neck lumps outside the thyroid gland. A previous history of treated differentiated thyroid cancer (DTC) was given by 23 patients and of nonthyroidal malignancy by 3 patients. FNA- Tg was measured in the Tg-free serum used to wash out the needle employed for the cytology. Finally, all patients were treated by surgery. FNA-Tg was always detectable in 14 patients with thyroid cancer metastases demonstrated by histology, with a mean (+/- SD) of 27,087 +/- 37,622 ng/FNA (P less than 0.002) compared to patients without thyroid cancer metastases (mean +/- SD, 12.1 +/- 4.8 ng/FNA in 7 cases; undetectable in 14 cases). Assuming 21.7 ng/FNA (the mean +/- 2 SD of the negative patients) as the cut-off value, all patients with metastases from DTC were detected by FNA-Tg. FNA-Tg had better negative predictive value than cytology, since this last technique gave 10 inconclusive results, comprising 2 false negative results in patients with metastases from DTC. Our results indicate that elevated concentrations of FNA-Tg in nonthyroidal neck nodes strongly suggest the diagnosis of metastases from DTC.


This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
A.-L. Borel, R. Boizel, P. Faure, G. Barbe, J. Boutonnat, N. Sturm, D. Seigneurin, I. Bricault, J.-P. Caravel, P. Chaffanjon, et al.
Significance of low levels of thyroglobulin in fine needle aspirates from cervical lymph nodes of patients with a history of differentiated thyroid cancer
Eur. J. Endocrinol., May 1, 2008; 158(5): 691 - 698.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. L. H. Snozek, E. P. Chambers, C. C. Reading, T. J. Sebo, J. W. Sistrunk, R. J. Singh, and S. K. G. Grebe
Serum Thyroglobulin, High-Resolution Ultrasound, and Lymph Node Thyroglobulin in Diagnosis of Differentiated Thyroid Carcinoma Nodal Metastases
J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4278 - 4281.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Leboulleux, E. Girard, M. Rose, J. P. Travagli, N. Sabbah, B. Caillou, D. M. Hartl, N. Lassau, E. Baudin, and M. Schlumberger
Ultrasound Criteria of Malignancy for Cervical Lymph Nodes in Patients Followed Up for Differentiated Thyroid Cancer
J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3590 - 3594.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
N. Cunha, F. Rodrigues, F. Curado, O. Ilheu, C. Cruz, P. Naidenov, M. J. Rascao, J. Ganho, I. Gomes, H. Pereira, et al.
Thyroglobulin detection in fine-needle aspirates of cervical lymph nodes: a technique for the diagnosis of metastatic differentiated thyroid cancer
Eur. J. Endocrinol., July 1, 2007; 157(1): 101 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Boi, I. Maurelli, G. Pinna, F. Atzeni, M. Piga, M. L. Lai, and S. Mariotti
Calcitonin Measurement in Wash-Out Fluid from Fine Needle Aspiration of Neck Masses in Patients with Primary and Metastatic Medullary Thyroid Carcinoma
J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2115 - 2118.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Boi, G. Baghino, F. Atzeni, M. L. Lai, G. Faa, and S. Mariotti
The Diagnostic Value for Differentiated Thyroid Carcinoma Metastases of Thyroglobulin (Tg) Measurement in Washout Fluid from Fine-Needle Aspiration Biopsy of Neck Lymph Nodes Is Maintained in the Presence of Circulating Anti-Tg Antibodies
J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1364 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Wartofsky
Management of Patients with Scan Negative, Thyroglobulin Positive Differentiated Thyroid Carcinoma
J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4195 - 4199.
[Full Text]

Home page
 NEJMHome page
M. J. Schlumberger
Papillary and Follicular Thyroid Carcinoma
N. Engl. J. Med., January 29, 1998; 338(5): 297 - 306.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1992 by The Endocrine Society