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Journal of Clinical Endocrinology & Metabolism, Vol 74, 1372-1377, Copyright © 1992 by Endocrine Society

ARTICLES

Transthyretin (prealbumin) in the pancreas and sera of newly diagnosed type I (insulin-dependent) diabetic patients

N Itoh, T Hanafusa, J Miyagawa, S Tamura, M Inada, S Kawata, N Kono and S Tarui
Second Department of Internal Medicine, Osaka University Medical School, Japan.

We investigated transthyretin (TTR) in the pancreases and sera of 10 newly diagnosed type I diabetic patients by immunohistochemistry and nephelometry. In the type I diabetic pancreases, glucagon-positive A- cells showed strong immunoreactivity for TTR, the intensity and distribution pattern of which corresponded to those in normal subjects. Morphometric analysis revealed that the amount of strongly TTR-positive A-cells was not significantly different from that in normal subjects. On the contrary, insulin-positive B-cells, which normally show uneven and weak TTR immunoreactivity, decreased in number, and only a few residual B-cells showed faint immunoreactivity. Neither somatostatin cells nor pancreatic polypeptide cells were positive for TTR. The serum TTR concentration showed a significant decrease in type I diabetic patients compared with that in normal subjects (P less than 0.005). These data suggest that the synthesis or storage of TTR in A-cells is not affected, but that in B-cells is impaired in type I diabetes. The decrease in serum TTR might be one of the features of metabolic disorders in type I diabetes.


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E. Refai, N. Dekki, S.-N. Yang, G. Imreh, O. Cabrera, L. Yu, G. Yang, S. Norgren, S. M. Rossner, L. Inverardi, et al.
Transthyretin constitutes a functional component in pancreatic {beta}-cell stimulus-secretion coupling
PNAS, November 22, 2005; 102(47): 17020 - 17025.
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