help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kawamura, N.
Right arrow Articles by Taniguchi, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kawamura, N.
Right arrow Articles by Taniguchi, N.

Journal of Clinical Endocrinology & Metabolism, Vol 74, 1352-1354, Copyright © 1992 by Endocrine Society

ARTICLES

Increased glycated Cu,Zn-superoxide dismutase levels in erythrocytes of patients with insulin-dependent diabetis mellitus

N Kawamura, T Ookawara, K Suzuki, K Konishi, M Mino and N Taniguchi
Department of Biochemistry, Osaka University Medical School, Japan.

Our previous study indicated that erythrocyte Cu,Zn-superoxide dismutase (Cu,Zn-SOD) undergoes glycation and inactivation in vivo (1) and in vitro (2). The aim of the present study was to assess glycated Cu,Zn-SOD in patients with insulin-dependent diabetes mellitus. Glycated Cu,Zn-SOD, which binds to a boronic acid affinity column, was measured by the enzyme-linked immunosorbent assay. The percentage of the glycated form in 25 insulin-dependent diabetic children was 40.2 +/- 8.2%; this was significantly higher than that in the normal controls (P less than 0.01). The specific activity of the glycated form in the diabetic children was 163,000 +/- 33,000 IU/mg Cu,Zn-SOD protein, significantly lower than that in controls (P less than 0.01). These data indicate that glycated and less active Cu,Zn-SOD is increased in erythrocytes of patients with insulin-dependent diabetes mellitus.


This article has been cited by other articles:


Home page
 Postgrad. Med. J.Home page
E. Szaleczky, J. Prechl, J. Fehér, and A. Somogyi
Alterations in enzymatic antioxidant defence in diabetes mellitus - a rational approach
Postgrad. Med. J., January 1, 1999; 75(879): 13 - 17.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Ookawara, N. Imazeki, O. Matsubara, T. Kizaki, S. Oh-Ishi, C. Nakao, Y. Sato, and H. Ohno
Tissue distribution of immunoreactive mouse extracellular superoxide dismutase
Am J Physiol Cell Physiol, September 1, 1998; 275(3): C840 - C847.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1992 by The Endocrine Society