Journal of Clinical Endocrinology & Metabolism, Vol 74, 543-547, Copyright © 1992 by Endocrine Society

ARTICLES

Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth

JW Koper, R Markstein, C Kohler, DJ Kwekkeboom, CJ Avezaat, SW Lamberts and JC Reubi
Department of Medicine, Erasmus University Rotterdam, The Netherlands.

It has been reported previously that most human meningiomas have receptors for somatostatin. Here we report the results of investigations of the effect of somatostatin and the somatostatin analog octreotide on the growth in vitro of human meningioma cells. Neither somatostatin nor its analog showed a direct growth inhibitory action on cultured human meningioma cells. Rather, there was a slight but significant stimulation of growth in the presence of somatostatin. The somatostatin receptors in meningioma tissue were shown to be functional since somatostatin inhibited forskolin-stimulated formation of cAMP by meningioma membranes. In addition, cAMP inhibited the growth of cultured meningioma cells. We conclude that the stimulation by somatostatin of the growth of human meningioma cells in vitro is caused by its inhibitory effect on cAMP formation. These results suggest that therapeutic trials of patients with (recurrent) inoperable meningiomas with somatostatin analogs have to be carried out with great caution.

This article has been cited by other articles:

				A. F. Muller, J. J. Kopchick, A. Flyvbjerg, and A. J. van der Lely Growth Hormone Receptor Antagonists J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1503 - 1511. [Full Text] [PDF]

				N D Stafford, L T Condon, M J C Rogers, L Helboe, D A Crooks, and S L Atkin The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas J. Clin. Pathol., February 1, 2004; 57(2): 168 - 171. [Abstract] [Full Text] [PDF]

				C. Meewes, K. H. Bohuslavizki, B. Krisch, J. Held-Feindt, E. Henze, and M. Clausen Molecular Biologic and Scintigraphic Analyses of Somatostatin Receptor-Negative Meningiomas J. Nucl. Med., September 1, 2001; 42(9): 1338 - 1345. [Abstract] [Full Text] [PDF]

				S. Schulz, S. U. Pauli, S. Schulz, M. Handel, K. Dietzmann, R. Firsching, and V. Hollt Immunohistochemical Determination of Five Somatostatin Receptors in Meningioma Reveals Frequent Overexpression of Somatostatin Receptor Subtype sst2A Clin. Cancer Res., May 1, 2000; 6(5): 1865 - 1874. [Abstract] [Full Text] [PDF]

				N. Douziech, E. Calvo, Z. Coulombe, G. Muradia, J. Bastien, R. A. Aubin, A. Lajas, and J. Morisset Inhibitory and Stimulatory Effects of Somatostatin on Two Human Pancreatic Cancer Cell Lines: A Primary Role for Tyrosine Phosphatase SHP-1 Endocrinology, February 1, 1999; 140(2): 765 - 777. [Abstract] [Full Text]