| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 74, 91-95, Copyright © 1992 by Endocrine Society
ARTICLES |
H Fujiwara, M Maeda, K Imai, M Fukuoka, K Yasuda, K Horie, K Takakura, S Taii and T Mori
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
The expression of aminopeptidase-N and neutral endopeptidase in human ovarian tissue was examined using specific monoclonal antibodies for each of these peptidases and histochemical staining for enzyme activity. Aminopeptidase-N is a membrane-bound metalloprotease catalyzing the removal of N-terminal amino acids from peptides and was detected by immunofluorescence staining on theca interna cells in secondary follicles and on luteinized thecal cells in preovulatory follicles and corpora lutea. However, aminopeptidase-N was not detected on granulosa cells. Peptidase activity was also detected by histochemical staining on theca interna cells and luteinized thecal cells. Luteinized granulosa cells showed peptidase activity, despite the lack of aminopeptidase-N. Neutral endopeptidase was not detected in ovarian granulosa and thecal cells. These observations indicate that aminopeptidase-N can be a useful surface marker for thecal cells.
This article has been cited by other articles:
 |
|
 |
|
  B. D. Looyenga and G. D. Hammer Origin and Identity of Adrenocortical Tumors in Inhibin Knockout Mice: Implications for Cellular Plasticity in the Adrenal Cortex Mol. Endocrinol., November 1, 2006; 20(11): 2848 - 2863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Egawa, S. Yoshioka, T. Higuchi, Y. Sato, K. Tatsumi, H. Fujiwara, and S. Fujii Ephrin B1 Is Expressed on Human Luteinizing Granulosa Cells in Corpora Lutea of the Early Luteal Phase: The Possible Involvement of the B Class Eph-Ephrin System during Corpus Luteum Formation J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4384 - 4392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yoshioka, H. Fujiwara, T. Higuchi, S. Yamada, M. Maeda, and S. Fujii Melanoma cell adhesion molecule (MCAM/CD146) is expressed on human luteinizing granulosa cells: enhancement of its expression by hCG, interleukin-1 and tumour necrosis factor-{alpha} Mol. Hum. Reprod., June 1, 2003; 9(6): 311 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Higuchi, H. Fujiwara, S. Yamada, K. Tatsumi, N. Kataoka, K. Itoh, M. Maeda, J. Fujita, and S. Fujii Co-expression of integrin-associated protein (IAP/CD47) and its ligand thrombospondin-1 on human granulosa and large luteal cells Mol. Hum. Reprod., October 1, 1999; 5(10): 920 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamada, H. Fujiwara, T. Honda, T. Higuchi, T. Nakayama, T. Inoue, M. Maeda, and S. Fujii Human granulosa cells express integrin {alpha}2 and collagen type IV: possible involvement of collagen type IV in granulosa cell luteinization Mol. Hum. Reprod., July 1, 1999; 5(7): 607 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yoshioka, H. Fujiwara, S. Yamada, K. Tatsumi, T. Nakayama, T. Higuchi, T. Inoue, M. Maeda, and S. Fujii Endothelin-Converting Enzyme-1 Is Expressed on Human Ovarian Follicles and Corpora Lutea of Menstrual Cycle and Early Pregnancy J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 3943 - 3950. [Abstract] [Full Text]
|
|
|
|
|
|
H. Fujiwara, T. Honda, M. Ueda, K. Nakamura, S. Yamada, M. Maeda, and T. Mori Laminin Suppresses Progesterone Production by Human Luteinizing Granulosa Cells via Interaction with Integrin {alpha}6{beta}1 J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2122 - 2128. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
