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Journal of Clinical Endocrinology & Metabolism Vol. 73, No. 6 1210-1215
doi:10.1210/jcem-73-6-1210
Copyright © 1991 by the Endocrine Society.
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Metabolism of Dehydroepiandrosterone Sulfate (DS) in Normal Women and Women with High DS Concentrations*

RAY V. HANING, Jr., IAN H. CARLSON, CHARLES A. FLOOD, RICHARD J. HACKETT and CHRISTOPHER LONGCOPE

Brown University and Women and Infants Hospital Providence, Rhode Island 02905
University Hospital Clinical Laboratories and University of Wisconsin Madison Wisconsin
Departments of Obstetrics and Gynecology and Medicine, University of Massachusetts Medical School Worcester, Massachusetts 01605

Address all correspondence and requests for reprints to: Ray V. Haning, Jr., M.D. Department of Obstetrics and Gynecology, Women and Infants Hospital, 101 Dudley Street, Providence, Rhode Island 02905.

In order to determine the contribution of serum dehydroepiandrosterone sulfate (DS) to estrone (E1) production in normal women and the effect of chronic elevation of the serum DS concentration on DS metabolism, four normal women and four women with high endogenous serum DS were infused with [3H]DS and [14C]E1 or [14C]testosterone for 6 h. Blood samples were analyzed for radioactivity as DS, dehydroepiandrosterone (D), androstenedione, testosterone, and dihydrotestosterone. Urine was collected for analysis of creatinine, 17- ketosteroids (17–KS), and radioactivity as estrone (E1). The serum DS of 12.4 ± 1.44 µmol/L (mean ± SE) in the group with high DS was higher than that of 3.96 ± 1.0 /nmol/L (1.46 ± 0.37 Mg/mL) in the normals (P < 0.005). Those with high DS also had increased 17-KS (13.2 ± 2.0 vs. 5.68 ± 0.68 mg/day, P < 0.025) and a higher blood production rate of DS (Formula ) (126 ± 21 (n = 3) vs. 54.3 ± 13.8 mmol/day, P < 0.05) but a lower MCRDS (10.94 ± 0.61 (n = 3) vs. 13.8 ± 0.27 L/day, P < 0.01) than that in normals. In the four normal women the fraction of infused DS converted to estrone Formula was 0.00078 ± 0.00018, the amount of E1 produced from serum DS was 41.3 ± 15 nmol/day, the basal plasma E1 was 102 ± 18 pmol/L, the MCREl was 1340 ± 181 L/day, the value for blood production of E1 Formula was 129 ± 12 nmol/day, and the portion of E1 derived from DS was 30.4 ± 9.4%. Correlation analysis of the data from these eight subjects showed that 17-KS, Formula , and the serum DS were all correlated with body surface area, body weight, and ponderal index and that 17-KS excretion, Formula , and serum DS were all correlated with one another. The most important predictors of 17-KS excretion were serum DS (P < 0.001) and the ponderal index (P < 0.05).

* This work was supported in part by NIH Grants R01-HD-21280 and 5-M01-RR-02038.

Received March 15, 1991.




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