help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Merimee, T. J.
Right arrow Articles by Riley, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Merimee, T. J.
Right arrow Articles by Riley, W.

Journal of Clinical Endocrinology & Metabolism, Vol 73, 1031-1037, Copyright © 1991 by Endocrine Society

ARTICLES

Hormone and receptor studies: relationship to linear growth in childhood and puberty

TJ Merimee, B Russell, S Quinn and W Riley
Department of Medicine, University of Florida, Gainesville 32610.

Preliminary data suggested different patterns of hormonal control of linear growth in males and females. To better define these patterns, serum samples were collected from 75-125 boys and a similar number from girls for each year of age between 3-16 yr (n = 2416). Fewer samples were collected from 2-yr-olds, newborns, and adults (n = 151). Samples for each age were aliquoted, combined, and assayed for GH, GH-binding protein (GHBP), insulin-like growth factor-I, and testosterone. GHBP, expressed as a percentage of the [125I]GH bound, increased yearly in males and females, with no relationship to the secretion of sex hormones. The increase in binding of [125I]GH and, by inference, GH receptors occurred at a greater rate between the ages of 2-10 yr than between 10-16 yr (in terms of absolute binding, 1.2 +/- 0.11% vs. 0.38 +/- 0.04% yearly; P less than 0.001). In each age group, however, the increase in GHBP exhibited a strong positive correlation with linear height (r = 0.96-0.98 in males; r = 0.92-0.99 in females). Before puberty, GH and insulin-like growth factor-I concentrations were consistently greater in females. Between 10-16 yr of age, height velocity (centimeters of growth per yr) correlated strongly with GH in girls (r = 0.86), but did not correlate with GH in boys of a similar age (r = -0.13). The major pubertal growth spurt in males strongly correlated with a rise in serum testosterone concentration beginning at age 11 yr (r = 0.92). Small peaks of GH secretion before and after the major period of accelerated growth in males possibly prolonged the major growth phase, but did not initiate it.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. Garzon, S. F. Soriano, J. M. Rodriguez-Frade, L. Gomez, A. Martin de Ana, M. Sanchez-Gomez, C. Martinez-A, and M. Mellado
CXCR4-mediated Suppressor of Cytokine Signaling Up-regulation Inactivates Growth Hormone Function
J. Biol. Chem., October 22, 2004; 279(43): 44460 - 44466.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
L. J. Herrinton and G. Husson
Relation of Childhood Height and Later Risk of Breast Cancer
Am. J. Epidemiol., October 1, 2001; 154(7): 618 - 623.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1991 by The Endocrine Society