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Journal of Clinical Endocrinology & Metabolism, Vol 73, 877-881, Copyright © 1991 by Endocrine Society

ARTICLES

Pheochromocytoma with pyrexia and marked inflammatory signs: a paraneoplastic syndrome with possible relation to interleukin-6 production

S Fukumoto, T Matsumoto, S Harada, J Fujisaki, M Kawano and E Ogata
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

Pheochromocytoma can cause several paraneoplastic syndromes. We report a patient with pheochromocytoma who exhibited pyrexia and marked inflammatory signs along with an elevated serum interleukin-6 (IL-6) level. All of these abnormalities disappeared and serum IL-6 became undetectable by removal of the tumor. In addition, immunohistochemical analysis revealed the presence of IL-6 in the tumor cells. It is suggested that pyrexia and the elevation of acute phase proteins can be a paraneoplastic syndrome with pheochromocytoma, and that the elaboration of IL-6 from pheochromocytoma may play an important role in the development of the syndrome.


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