help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hubert, G. D.
Right arrow Articles by Buster, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hubert, G. D.
Right arrow Articles by Buster, J. E.

Journal of Clinical Endocrinology & Metabolism, Vol 73, 781-784, Copyright © 1991 by Endocrine Society

ARTICLES

Suppression of circulating delta 4-androstenedione and dehydroepiandrosterone sulfate during oral glucose tolerance test in normal females

GD Hubert, ED Schriock, JR Givens and JE Buster
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38163.

Extending a series of previous investigations on the regulatory interaction of insulin and androgens, this study tests the hypothesis that the physiological insulinemia after oral glucose suppresses circulating dehydroepiandrosterone (DHEA), dehydroepiandrosterone- sulfate (DHEA-S), and androstenedione (delta 4A) delta 4 in normal women. Accordingly, seven normal weight, ovulatory women were randomized to receive first either a 75 g glucose dose or a sham control for diurnal rhythm consisting of distilled water at 1700 h. After this insulin stimulus, DHEA-S suppressed below sham control at 90 and 120 min (P less than 0.05) whereas delta 4A suppress at 60, 90, and 120 min (P less than 0.05). Furthermore, as serum insulin increased after glucose, DHEA-S (r2 = 0.351, P less than 0.05) and delta 4A (r2 = 0.314, P less than 0.05) decreased in an inverse linear relationship with insulin. There was no significant suppression below sham at any point in time for DHEA, testosterone, or cortisol. Thus, the endogenous serum insulin response after oral glucose in normal women is associated with suppression of serum DHEA-S and delta 4A with absence of testosterone and cortisol suppression.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
K. Mai, T. Bobbert, V. Kullmann, J. Andres, H. Rochlitz, M. Osterhoff, M. O. Weickert, V. Bahr, M. Mohlig, A. F. H. Pfeiffer, et al.
Free Fatty Acids Increase Androgen Precursors in Vivo
J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1501 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Remer, K. Pietrzik, and F. Manz
Short-Term Impact of a Lactovegetarian Diet on Adrenocortical Activity and Adrenal Androgens
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2132 - 2137.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1991 by The Endocrine Society