| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 72, 1169-1171, Copyright © 1991 by Endocrine Society
ARTICLES |
TJ Smith, RS Bahn, CA Gorman and M Cheavens
Department of Medicine, Albany Medical College, N.Y.
Fully expressed Graves' disease involves an accumulation of glycosaminoglycan (GAG) in the retroocular connective tissue which contributes to the pathogenesis of ophthalmopathy. We treated cultured retroocular and dermal fibroblasts with recombinant interferon gamma (100 U/ml) for 16-24h and measured [3H]GAG accumulation. The cytokine stimulated [3H]GAG accumulation in retroocular fibroblast cultures obtained from eight different donors by 36-124% above control values. In contrast, interferon gamma had no consistent effect on macromolecular accumulation in dermal fibroblast cultures derived from the pretibium or from areas ordinarily uninvolved in Graves' dermopathy. These results suggest that retroocular fibroblasts may be uniquely targeted for one action of interferon gamma which involves the modulation of GAG metabolism.
This article has been cited by other articles:
 |
|
 |
|
  T J Cawood, P Moriarty, C O'Farrelly, and D O'Shea The effects of tumour necrosis factor-{alpha} and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis Eur. J. Endocrinol., September 1, 2006; 155(3): 395 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Prabhakar, R. S. Bahn, and T. J. Smith Current Perspective on the Pathogenesis of Graves' Disease and Ophthalmopathy Endocr. Rev., December 1, 2003; 24(6): 802 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Fatourechi, D. D. F. Ahmed, and K. M. Schwartz Thyroid Acropachy: Report of 40 Patients Treated at a Single Institution in a 26-Year Period J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5435 - 5441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Smith, L. Koumas, A. Gagnon, A. Bell, G. D. Sempowski, R. P. Phipps, and A. Sorisky Orbital Fibroblast Heterogeneity May Determine the Clinical Presentation of Thyroid-Associated Ophthalmopathy J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 385 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bartalena, A. Pinchera, and C. Marcocci Management of Graves' Ophthalmopathy: Reality and Perspectives Endocr. Rev., April 1, 2000; 21(2): 168 - 199. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Sciaky, W. Brazer, D. M. Center, W. W. Cruikshank, and T. J. Smith Cultured Human Fibroblasts Express Constitutive IL-16 mRNA: Cytokine Induction of Active IL-16 Protein Synthesis Through a Caspase-3-Dependent Mechanism J. Immunol., April 1, 2000; 164(7): 3806 - 3814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Cao and T. J. Smith Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts Am J Physiol Cell Physiol, December 1, 1999; 277(6): C1075 - C1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Kaback and T. J. Smith Expression of Hyaluronan Synthase Messenger Ribonucleic Acids and Their Induction by Interleukin-1{beta} in Human Orbital Fibroblasts: Potential Insight into the Molecular Pathogenesis of Thyroid-Associated Ophthalmopathy J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4079 - 4084. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. J. Smith and S. J. Parikh HMC-1 Mast Cells Activate Human Orbital Fibroblasts in Coculture: Evidence for Up-Regulation of Prostaglandin E2 and Hyaluronan Synthesis Endocrinology, August 1, 1999; 140(8): 3518 - 3525. [Abstract] [Full Text]
|
|
|
|
|
|
C. Hansen, R. Rouhi, G. Förster, and G. J. Kahaly Increased Sulfatation of Orbital Glycosaminoglycans in Graves' Ophthalmopathy J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1409 - 1413. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. J. Cao, H.-S. Wang, Y. Zhang, H.-Y. Lin, R. P. Phipps, and T. J. Smith Activation of Human Orbital Fibroblasts through CD40 Engagement Results in a Dramatic Induction of Hyaluronan Synthesis and Prostaglandin Endoperoxide H Synthase-2 Expression. INSIGHTS INTO POTENTIAL PATHOGENIC MECHANISMS OF THYROID-ASSOCIATED OPHTHALMOPATHY J. Biol. Chem., November 6, 1998; 273(45): 29615 - 29625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Spicer, L. A. Kaback, T. J. Smith, and M. F. Seldin Molecular Cloning and Characterization of the Human and Mouse UDP-Glucose Dehydrogenase Genes J. Biol. Chem., September 25, 1998; 273(39): 25117 - 25124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Young, C. H. Evans, and T. J. Smith Leukoregulin induction of protein expression in human orbital fibroblasts: Evidence for anatomical site-restricted cytokine-target cell interactions PNAS, July 21, 1998; 95(15): 8904 - 8909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Sempowski, J. Rozenblit, T. J. Smith, and R. P. Phipps Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production Am J Physiol Cell Physiol, March 1, 1998; 274(3): C707 - C714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A Burnstine, S. G Elner, and V. M Elner Orbital fibroblast chemokine modulation: effects of dexamethasone and cyclosporin A Br. J. Ophthalmol., March 1, 1998; 82(3): 318 - 322. [Abstract] [Full Text]
|
|
|
|
|
|
H.-S. Wang, H. J. Cao, V. D. Winn, L. J. Rezanka, Y. Frobert, C. H. Evans, D. Sciaky, D. A. Young, and T. J. Smith Leukoregulin Induction of Prostaglandin-Endoperoxide H Synthase-2 in Human Orbital Fibroblasts. AN IN VITRO MODEL FOR CONNECTIVE TISSUE INFLAMMATION J. Biol. Chem., September 13, 1996; 271(37): 22718 - 22728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Bahn and A. E. Heufelder Pathogenesis of Graves' Ophthalmopathy N. Engl. J. Med., November 11, 1993; 329(20): 1468 - 1475. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
