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Journal of Clinical Endocrinology & Metabolism Vol. 72, No. 4 747-754
doi:10.1210/jcem-72-4-747
Copyright © 1991 by the Endocrine Society.
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A Chorionic Gonadotropin-Secreting Human Pituitary Cell*

E. HAMMOND, J. GRIFFIN and W. D. ODELL

Departments of Medicine and Pathology, University of Utah School of Medicine Salt Lake City, Utah 84132

Address all correspondence and requests for reprints to: William D. Odell, M.D., Ph.D., University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132.

Recent data from our laboratory show that hCG is secreted in a pulsatile manner in parallel with human LH (hLH) in nonpregnant normal humans. Furthermore, GnRH stimulates hCG and hLH release. Using a monoclonal antibody specific for the β-chain of hCG and not reacting with hLH, we have identified a heretofore unknown cell type in human pituitaries which stains only for hCG. The light microscopic, immunocytochemical, and ultrastructural features are described. These data coupled to those from multiple earlier studies indicate that hCG is secreted by these cells in normal nonpregnant humans. (J Clin Endocrinol Metab 72: 747–754, 1991)

* This work was supported by a grant from the NIH. Presented at the 70th Annual Meeting of The Endocrine Society, New Orleans, LA, June 8–11, 1988 (Abstract 49).

Received August 23, 1989.




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Copyright © 1991 by The Endocrine Society