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Journal of Clinical Endocrinology & Metabolism Vol. 72, No. 3 727-729
doi:10.1210/jcem-72-3-727
Copyright © 1991 by the Endocrine Society.
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THE N-TERMINAL SEQUENCE OF THE MAJOR ERYTHROPOIETIC FACTOR OF AN ANEPHRIC PATIENT IS IDENTICAL TO INSULIN-LIKE GROWTH FACTOR I.

L.F. Congote*, A. Brox**, F.K. Lin*, H.S. Lu* and A.A. Fauser**

* Endocrine Laboratory Montreal, Canada, H3A 1A1.
** Division of Hematology Montreal, Canada, H3A 1A1.
Royal Victoria Hospital and Department of Medicine, McGill University Montreal, Canada, H3A 1A1.
* Amgen Thousand Oaks, CA 91320

The erythropoietic factors present in an anephric patient with nearly normal hematocrit were isolated from plasma by reversed-phase and gel permeation HPLC. The most active fraction was purified and the analysis of its N-terminal sequence was identical to the published sequence of the human insulin-like growth factor I (IGF I). Recombinant human IGF I had identical edition positions as the isolated erythropoietic factor on reversed-phase HPLC and the same molecular weight on gel permeation HPLC. Furthermore. hrIGF I stimulated erythroid colony formation in human bone marrow cultures as was previously shown for the isolated human erythropoietic factor. These results suggest that IGF I may replace erythropoietin as a stimulator of erytliropoiesis in some patients with anemia and renal failure.

Received September 7, 1990.




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Copyright © 1991 by The Endocrine Society