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Serum Gonadotropin, Sex Steroid, and Immunoreactive Inhibin Levels in the First Two Years of Life^*

Prince Henry’s Institute of Medical Research (H.G.B., M.L.B.); the Department of Mathematics, Monash University (P.I.M.); and the Department of Endocrinology and Diabetes, Royal Children’s Hospital (Y.Y., G.L.W.) Melbourne, Australia

Address all correspondence and requests for reprints to: Prof. H. G. Burger, Prince Henry’s Institute of Medical Research, P.O. Box 118, South Melbourne Victoria 3205, Australia.

To characterize the changes in serum immunoreactive inhibin (INH) in the first 2 yr of life, blood samples were obtained from 46 boys (age range, 61–659 days) and 37 girls (76–666 days) undergoing minor surgery for nonendocrine related conditions. Serum levels were compared with those of simultaneously measured FSH, LH, and either testosterone (T) or estradiol (E₂). In the boys, the levels of all 4 hormones fell progressively with age up to about 300 days, with a minor fall only in the second year. FSH (0.7–1.4 IU/L) was initially at the lower adult male limit, while LH (3.2–5.0 IU/L) was at the midrange. T levels (2.2–3.3 nmol/L) were in the adult female range, while INH (200–820 U/L) was in the midrange for men. In the youngest girls, FSH levels (12–26 IU/L) were frequently above the upper limit of normal for the adult follicular phase, but fell to approximately 2.0 IU/L after 300 days. LH levels (0.5–3.5 IU/L) were at the lower adult normal limit and changed little with age, while E₂ levels in the youngest girls (280–550 pmol/L) were in the midfollicular range, but were generally less than 10 pM at more than 200 days. INH levels (175–260 U/L) were in the low adult range initially, but the majority were undetectable over 200 days. In the boys, significant negative correlations were observed for all 4 hormones with age, while FSH, LH, and T were positively correlated with INH. In the girls, there were weaker negative correlations of the 4 hormones with age, but no significant correlations between the gonadotropins and INH. E₂ was strongly correlated with INH. Thus, the previously described early postnatal activation of the hypothalamo-pituitary-gonadal axis involves INH as well as the sex steroids and gonadotropins. FSH levels in young girls were strikingly high, and INH levels were much higher in boys than girls. The low INH levels in girls may contribute to the elevated FSH seen during the period of neonatal gonadal activation.

^* This work was supported by the National Health and Medical Research Council of Australia.

Received July 2, 1990.

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