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Correlation between Serum Osteocalcin and 24,25-Dihydroxyvitamin D Levels in Paget's Disease of Bone^*

Unidad Metabólica, Fundación Jiménez Díaz 28040 Madrid, Spain

Address all correspondence and requests for reprints to: C. de Piedra, Laboratorio de la Unidad Metabólica, Fundación Jiménez Díaz, Avda Reyes Católicos 2, 28040 Madrid, Spain.

We have studied the possible correlation between serum 24,25-dihydroxyvitamin D [24,25-(OH)₂D] and osteocalcin levels (sBGP) in Paget's disease of bone. We measured serum calcium, phosphate, PTH, 25-hydroxyvitamin D, 1,25-(OH)₂D, 24,25-(OH)₂D, alkaline phosphatase (sAP), and the urinary hydroxyproline/creatinine ratio (UOH prol/creat) in 19 patients with Paget's disease of bone and 16 age- and sexmatched controls. As expected, sAP, UOH prol/creat, and sBGP levels were significantly elevated, and there was a tendency to a decrease in serum levels of 24,25-(OH)₂D in Pagetic patients with respect to the control group. There was no significant difference between patients and controls in serum calcium, phosphate, PTH, 25-hydroxyvitamin D, and 1,25-(OH)₂D. The Pagetic patients were subdivided into two subgroups; subgroup A had normal sBGP levels (<5 ng/mL), and subgroup B had increased sBGP levels (>5 ng/mL). Serum 24,25-(OH)₂D levels in subgroup B were significantly lower than those in controls, while subgroup A showed leve.s similar to those in the control group. We also found a positive linear correlation between sAP and sBGP and between sAP and UOH prol/creat as well as a negative linear correlation between sBGP and 24,25-(OH)₂D and between 24,25-(OH)₂D ami UOH prol/creat in Pagetic patients. These results point to a possible role of 24,25-(OH)₂D in disease activity.

^* This work was supported in part by a grant from the Spanish Institute of Health (FISss 88/1536).

Received December 8, 1989.