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Journal of Clinical Endocrinology & Metabolism, Vol 72, 65-68, Copyright © 1991 by Endocrine Society
ARTICLES |
TD Shultz
Department of Food Science and Human Nutrition, Washington State University, Pullman 99164-6376.
Consumption of dietary fat has been linked to the high incidence of breast cancer. The in vitro effects of palmitate, oleate, linoleate, and eicosapentaenoate at supraphysiological concentrations [1.8-4.8 mM; endogenous (0.8) plus added (1-4)] on the binding of 17 beta-estradiol (E2) to sex hormone-binding globulin and albumin were evaluated in plasma, using centrifugal ultrafiltration. The E2-sex hormone-binding globulin complex was significantly dissociated by oleate, linoleate, eicosapentaenoate, and palmitate at 1.8 to 2.8-mM concentrations. The same FFA caused a significant increase in E2 binding to albumin at similar concentrations. However, only the unsaturated fatty acids at 3.8 to 4.8-mM concentrations (i.e. oleate, linoleate, and eicosapentaenoate) significantly increased the nonprotein-bound free E2 fraction. Thus, these results suggest that free E2 concentrations are not affected by physiological concentrations of FFA.
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