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Journal of Clinical Endocrinology & Metabolism, Vol 72, 51-59, Copyright © 1991 by Endocrine Society

ARTICLES

Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man

JD Veldhuis, A Iranmanesh, KK Ho, MJ Waters, ML Johnson and G Lizarralde
Division of Endocrinology and Metabolism, University of Virginia, Charlottesville 22908.

We have examined the mechanisms underlying reduced circulating GH concentrations in the obese human. Computer-assisted (deconvolution) analysis was used to determine endogenous GH secretory and clearance rates quantitatively from entire 24-h plasma GH concentration profiles. These analyses revealed that the half-life (t 1/2) of endogenous GH was significantly shorter in obese (11.7 +/- 1.6 min) than in normal weight subjects (15.5 +/- 0.81 min; P less than 0.01). The accelerated blood disposal rate of GH was not due to decreased circulating concentrations of GH-binding protein, since the latter were similar in obese (25 +/- 1.0%) and normal weight (24 +/- 2.3%) men. However, obese men had significantly fewer GH secretory bursts (3.2 +/- 0.53 vs. 9.7 +/- 0.67/day; P less than 0.01). Among the rare GH secretory bursts that occurred in obese subjects, there were significantly prolonged mean intersecretory burst intervals (282 +/- 65 vs. 131 +/- 11 min; P less than 0.05). The resultant daily GH production rate in obese men was reduced to one fourth that in normal weight individuals. Both GH secretion rate and burst frequency were negatively correlated with the degree of obesity (ponderal index). The decreases in GH burst frequency and half-life were specific, since GH secretory pulse amplitude (maximal rate of GH release), the mass of GH released per burst, and the duration of computer-resolved GH secretory bursts were not different in obese and normal weight men. We conclude that obese men harbor a double defect in GH dynamics involving both GH secretion and clearance, and that the severity of the GH secretory deficiency is proportionate to the degree of obesity.


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N. Vahl, N. Moller, T. Lauritzen, J. S. Christiansen, and J. O. L. Jorgensen
Metabolic Effects and Pharmacokinetics of a Growth Hormone Pulse in Healthy Adults: Relation to Age, Sex, and Body Composition
J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3612 - 3618.
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M. Scacchi, A. I. Pincelli, A. Caumo, P. Tomasi, G. Delitala, G. Baldi, and F. Cavagnini
Spontaneous Nocturnal Growth Hormone Secretion in Anorexia Nervosa
J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3225 - 3229. <