| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Departments of Obstetrics and Gynecology, University Central Hospital, Helsinki (E.-M.R.) and Department of Pathology (S.P.), Jorvi Hospital Espoo
the Minerva Institute for Medical Research (F.P.) Helsinki, Finland
Address all correspondence and requests for reprints to: Dr. E.-M. Rutanen, Minerva Institute for Medical Research, Tukholmankatu 2, SF-00250 Helsinki, Finland.
Human extrauterine decidual cells were studied for the presence of insulin-like growth factor-binding protein-1 (IGFBP-1) by using an avidin-biotin complex immunoperoxidase method with a purified monoclonal antibody 6303 against IGFBP-1. It is well established that human decidua expresses mRNA for IGFBP-1 and synthesizes and secretes this protein. We now describe, for the first time, that cells morphologically similar to uterine decidual cells found beneath the peritoneal mesothelium in inguinal hernia and in the cervical mucosa during normal pregnancy and in the mesenchymal tissue of the Fallopian tubes and ovaries at term react with the monoclonal antibody for IGFBP-1 equally to endometrial decidual cells. These results imply that the extrauterine mesenchymal cells, which have undergone decidual transformation, are not only morphologically but also functionally, similar to their counterparts in the uterus. Secondly, the data suggest that IGFBP-1 expression is associated with a special type(s) of cells and a certain stage of differentiation rather than special organs in the body.
Received March 9, 1991.
This article has been cited by other articles:
![]() |
H. Matsumoto, K. Sakai, and M. Iwashita Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via {alpha}5{beta}1 integrin Mol. Hum. Reprod., August 1, 2008; 14(8): 485 - 489. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Hurskainen, A. Salmi, J. Paavonen, J. Teperi, and E.-M. Rutanen Expression of sex steroid receptors and Ki-67 in the endometria of menorrhagic women: effects of intrauterine levonorgestrel Mol. Hum. Reprod., November 1, 2000; 6(11): 1013 - 1018. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Zygmunt, D.M. Mazzuca, J. Walton, and V.K.M. Han Local fetal signal is not required for maintaining IGFBP gene expression in the human decidua: evidence from extrauterine pregnancies Mol. Hum. Reprod., October 1, 2000; 6(10): 959 - 965. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |