help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iranmanesh, A.
Right arrow Articles by Veldhuis, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iranmanesh, A.
Right arrow Articles by Veldhuis, J. D.

Journal of Clinical Endocrinology & Metabolism, Vol 72, 108-115, Copyright © 1991 by Endocrine Society


ARTICLES

Nature of altered growth hormone secretion in hyperthyroidism

A Iranmanesh, G Lizarralde, ML Johnson and JD Veldhuis
Department of Internal Medicine, Salem Veterans Administration Hospital, Virginia 24153.

Hyperthyroidism is accompanied by various neuroendocrine regulatory disturbances that affect not only the thyrotropic, but also the gonadotropic, corticotropic, and somatotropic axes. To examine the nature of alterations in neuroendocrine control mechanisms that direct the somatotropic axis in hyperthyroidism, we have applied a novel deconvolution technique designed to estimate the number, amplitude, and mass of significant underlying GH secretory events after the influence of GH metabolic clearance has been removed mathematically. To this end, blood was sampled at 10-min intervals for 24 h in seven hyperthyroid and seven age-matched euthyroid men. The subsequent GH time series were assayed by immunoradiometric assay (sensitivity, 0.08 ng/mL) and submitted to quantitative deconvolution analysis. We found that hyperthyroid compared to euthyroid men 1) had significantly more GH secretory bursts per 24 h (viz. 15 +/- 1.0 vs. 10 +/- 1.1; P = 0.017); 2) secreted 3 times as much GH per burst (3.7 +/- 0.80 vs. 1.3 +/- 0.42 ng/mL distribution vol; P = 0.013); 3) achieved a maximal rate of GH secretion in each burst 2.3-fold higher than that in control men (0.14 +/- 0.028 vs. 0.060 +/- 0.015 ng/mL.min; P = 0.017); and 4) had 3.7- fold higher 24-h endogenous GH production rates (P less than 0.01). Neither hyperthyroid nor euthyroid men had significant interburst (tonic) GH secretion. We conclude that the somatotropic axis in hyperthyroid men is marked by a higher frequency of spontaneous GH secretory bursts, a higher rate of maximal GH secretion attained per burst, and a larger mass of GH released per burst. These neuroregulatory disturbances result in a nearly 4-fold increase in the 24-h production rate of GH in thyrotoxicosis.


This article has been cited by other articles:


Home page
Eur J EndocrinolHome page
A. Alkemade, E. C Friesema, G. G Kuiper, W. M Wiersinga, D. F Swaab, T. J Visser, and E. Fliers
Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary.
Eur. J. Endocrinol., March 1, 2006; 154(3): 491 - 500.
[Abstract] [Full Text] [PDF]


Home page
Eur J EndocrinolHome page
O. Gimenez-Palop, G. Gimenez-Perez, D. Mauricio, E. Berlanga, N. Potau, C. Vilardell, J. Arroyo, J.-M. Gonzalez-Clemente, and A. Caixas
Circulating ghrelin in thyroid dysfunction is related to insulin resistance and not to hunger, food intake or anthropometric changes
Eur. J. Endocrinol., July 1, 2005; 153(1): 73 - 79.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. L. D. Riis, J. O. L. Jorgensen, S. Gjedde, H. Norrelund, A. G. Jurik, K. S. Nair, P. Ivarsen, J. Weeke, and N. Moller
Whole body and forearm substrate metabolism in hyperthyroidism: evidence of increased basal muscle protein breakdown
Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1067 - E1073.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child.Home page
G Birrell and T Cheetham
Juvenile thyrotoxicosis; can we do better?
Arch. Dis. Child., August 1, 2004; 89(8): 745 - 750.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
A. L. D. Riis, T. K. Hansen, N. Moller, J. Weeke, and J. O. L. Jorgensen
Hyperthyroidism Is Associated with Suppressed Circulating Ghrelin Levels
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 853 - 857.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
A. Giustina and J. D. Veldhuis
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human
Endocr. Rev., December 1, 1998; 19(6): 717 - 797.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
Y. B. Sverrisdóttir, M. Elam, H. Herlitz, B.-A. Bengtsson, and G. Johannsson
Intense Sympathetic Nerve Activity in Adults with Hypopituitarism and Untreated Growth Hormone Deficiency
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 1881 - 1885.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1991 by The Endocrine Society