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Journal of Clinical Endocrinology & Metabolism, Vol 71, 1681-1683, Copyright © 1990 by Endocrine Society
ARTICLES |
K Takahashi, LC Lai, MA Ghatei, VH James and SR Bloom
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Immunoreactive endothelin has been detected in 21 of 43 samples of breast cyst fluid (21 cases; 3.5 +/- 0.6 pmol/l, mean +/- SEM. Other 22 cases; not detectable, less than 0.5 pmol/l). Fast protein liquid chromatographic analysis of the immunoreactive endothelin of pooled breast cyst fluid showed two immunoreactive peaks; one in the void volume and the other in the position of endothelin-1. It is probable that endothelin-1 is produced by the epithelial cells lining breast cysts, but significance of the presence of endothelin-1 in breast cyst fluid remains to be elucidated.
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