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Journal of Clinical Endocrinology & Metabolism, Vol 71, 1666-1668, Copyright © 1990 by Endocrine Society

ARTICLES

Anti-5 alpha-reductase autoantibodies in the serum of patients with prostatic cancer

T Liang, RA Hiipakka, J Stebbins and S Liao
Ben May Institute, Department of Medicine, University of Chicago, Illinois 60637.

Human sera were tested for their ability to inhibit 5 alpha-reductase binding of a potent inhibitor of the enzyme. Thirty one of 227 serum samples from patients diagnosed or suspected of prostatic cancer had a significant inhibitory activity, whereas 128 serum samples from other patients were inactive. The majority of the inhibitory activity was in the IgG fraction purified by chromatography on a protein A-Sepharose affinity column and an anti-human IgG-agarose column. IgG fractions from non-inhibitory sera were inactive. Inhibitory IgG also inhibited the enzymatic activity of microsomal 5 alpha-reductase from liver, ventral prostate and preputial gland of rat, and liver, prostate, and facial skin of human. The inhibitory IgG had no effect on NADH- menadione reductase or 17 beta-hydroxysteroid dehydrogenase. These results suggest that 5 alpha-reductase autoantibodies are present in the blood of some prostatic cancer patients.


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[Abstract] [Full Text] [PDF]


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